Preclinical cardiovascular sympathoexcitatory effects of TD-9855, a novel norepinephrine transporter (NET) inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension (nOH) in patients with primary autonomic failure
Objective: TD-9855 is a novel NET inhibitor (1) being studied for the treatment of symptomatic nOH. The objective of the present study was to characterize…Neurogenic Orthostatic Hypotension Burden of Illness Patient and Caregiver Survey: Impact of Symptoms
Objective: To determine the impact of neurogenic orthostatic hypotension (nOH) on the quality of life (QoL) of patients with autonomic dysfunction and the burden on…Patient-Reported Outcomes in a Prospective Real-World Study of Droxidopa for the Treatment of Neurogenic Orthostatic Hypotension
Objective: To assess the effect of droxidopa treatment on function, depression, and health-related quality of life (HRQoL) in patients with neurogenic orthostatic hypotension (nOH). Background:…A survey-based analysis of abnormal movements in patients with Postural Tachycardia Syndrome (PoTS)
Objective: The aim of this study is to evaluate the characteristics of PoTS associated tremor. Background: Postural tachycardia syndrome (PoTS) is a dysautonomia most prevalent…Assessment of Autonomic Dysfunction in Parkinson’s Disease
Objective: Assessment of autonomic dysfunction in patients with Parkinson's disease and further comparison with patients without autonomic symptoms Background: A frequent disabling complication of Parkinson’s…Predictor of progressive mild cognitive impairment in patients with Parkinson’s disease.
Objective: To clarify clinical features of patients with progressive mild cognitive impairment patients (MCI) in Parkinson’s disease (PD-MCI). Background: Non-demented PD subjects have MCI and…Effect of Droxidopa Treatment on Fear of Falling in Patients With Neurogenic Orthostatic Hypotension: Clinical Trial and “Real World” Results
Objective: To assess the impact of droxidopa on fear of falling in patients with symptomatic neurogenic orthostatic hypotension (nOH) in 2 studies. Background: nOH results…Falls characteristics of male and female patients with Parkinson’s disease (PD)
Objective: To compare Falls risk characteristics in male and female PD patients attending a multidisciplinary Movement disorders clinic. Background: Parkinson’s disease is commoner in males.…Burden of autonomic neuropathy in Parkinson’s disease patients treated with advanced therapies
Objective: To analyze the prevalence and the functional burden of autonomic neuropathy (AN) in advanced Parkinson’s disease (PD) patients who underwent subthalamic deep brain stimulation…Where Are The Main Lesions That Cause Orthostatic Hypotension In Parkinson’s Disease ?
Objective: To clarify the responsible lesion of orthostatic hypotension (OH) in Parkinson’s disease (PD) by measuring the catecholamine level and using a cardiac MIBG scintigraphy.…
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