Evaluation of Cortical Excitability in Huntington’s Disease and Parkinson’s Disease
Objective: To evaluate the cortical excitability difference in Huntington's disease (HD) and Parkinson's disease (PD) using paired-pulse transcranial magnetic stimulation (TMS). Background: TMS is useful…Repetitive transcranial magnetic stimulation (rTMS) fails to improve cognition in patients with Parkinson’s disease: a meta-analysis of randomized controlled trials
Objective: This study aimed to evaluate the effects of rTMS for improving cognition of PD patients. Background: Up to 20%–50% of patients with Parkinson’s disease…Moderately frequent and private variants in PRKN are associated with late-onset Parkinson’s disease
Objective: We hypothesized that heterozygosity for rare coding variants in PRKN, PINK1 or PARK7 might also represent a risk factor for sporadic late-onset PD.[4] Background:…Whole-exome sequencing in early-onset Parkinson’s disease among ethnic Chinese
Objective: The objectives of this study were to assess the genetic and clinical features of early-onset Parkinson’s disease (EOPD) among ethnic Chinese from mainland China.…PARK2 p.Ala82Glu variant is not associated with Parkinson’s disease
Objective: The aim of the study was to analyze potential pathogenicity of the PARK2 p.Ala82Glu mutation, by functional studies of Parkin in the mitophagy paradigm…Interest of multiplex ligation-dependent probe amplification assay to identify pathogenic mutations in Parkinson’s disease patients
Objective: To evaluate the interest of the MLPA (Multiplex Ligation-dependent Probe Amplification) commercially available kit in the genetic testing in Parkinson’s disease (PD). Background: PD…The First-Ever CNV Analysis in Latin American Parkinson’s Disease Patients
Objective: To assess the CNV burden in a cohort of Latin American Parkinson’s disease (PD) patients and controls. Background: Despite the fact that PD prevalence…Is early-onset of levodopa-induced dyskinesia a predictor of GBA mutation? A next-generation sequencing study of young-onset Parkinson’s disease patients in Thailand
Objective: To examine the prevalence of genetic causes in young-onset Parkinson’s disease (YOPD) patients with levodopa-induced dyskinesia (LID) in Thailand using a next-generation sequencing (NGS)…Identifying healthy Parkin mutation carriers based on sensor-based posturography and gait analysis
Objective: To discriminate healthy Parkin mutation carriers from healthy non-mutation carriers using sensor-based motion analysis. Background: Identifying endophenotypes for PD is crucial for testing potential…Deep mitochondrial sequencing in Parkinson’s disease reveals possible genetic modifiers of reduced penetrance in Parkin/PINK1 mutation carriers
Objective: To discover potential penetrance biomarkers in mitochondrial DNA (mtDNA) for Parkin and PINK1 mutation carriers. Background: Biallelic mutations in Parkin and PINK1 are fully…
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