Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease: ADAPT-PD Trial: A Prospective Single-Blind, Randomized Crossover, Multi-Center Trial of Deep Brain Stimulation Adaptive Algorithms in Subjects with Parkinson’s Disease
Objective: To demonstrate safety and effectiveness of adaptive deep brain stimulation (aDBS) algorithms in subjects with Parkinson’s disease (PD). Background: DBS is an effective therapy…Oral Venglustat in Parkinson’s Disease Patients With a GBA Mutation: Study Design of Part 2 of the MOVES-PD Trial and Patient Characteristics
Objective: Describe the study design of Part 2 of the MOVES-PD trial (NCT02906020), and report patient characteristics. Background: Mutations in the glucocerebrosidase (GBA) gene are…Prevalence and Characteristics of Postural Deformities in Thai Patients with Parkinson’s Disease
Objective: We aimed to investigate the prevalence, clinical characteristics and quality of life (QoL) in Thai Parkinson's disease (PD) patients with postural deformities (PostD) and…Motor subtype change between OFF and ON periods in patients with Parkinson’s disease
Objective: To identify if there is any difference in the motor subtype of PwPD between "off" stage and "on" stage. Background: Patients with Parkinson’s disease…New compound increasing glucocerebrosidase activity on primary cell cultures obtained from patients with GBA-associated Parkinson’s disease
Objective: To determine whether new chemical modifications of the previously described allosteric GCase chaperone N607 (Aflaki E et.al Neurosc. 2016) increase GCase activity in monocyte-derived…Disease stage and UMSARS progression: Implications for clinical trials
Objective: To study the rate of progression of multiple system atrophy (MSA) and assess for a potential ceiling effect of the Unified Multiple System Atrophy…Development and validation of a profile of peripheral immune biomarkers for Parkinson’s disease: A multicenter, retrospective study
Objective: This multicenter study was designed to investigate the association between multiple peripheral immune biomarkers and the risk of Parkinson’s disease (PD). Background: Several studies…Does “5-2-1” identify patients with suspected Advanced Parkinson’s Disease? Evidence of clinical accuracy from G7 countries
Objective: Evaluate the psychometric properties of (i) the “5-2-1” criteria and (ii) consensus-driven clinical indicators of suspected advanced Parkinson’s disease (APD). Background: Recent consensus panel…The efficacy of traditional Mikkyo Buddhism meditation in stress management of Parkinson’s syndrome patients
Objective: To investigate the efficacy of Asokukan in stress management of Parkinson’s syndrome patients. Background: Stress management is very important in intractable neurological diseases. Currently,…Improvement in the handicap is maintained after 5 years of deep brain stimulation in Parkinson’s disease
Objective: To characterize the handicap after 4.8 years of DBS-STN and to compare with pre-surgery data. Background: The London Handicap Scale (LHS) provide an overall…
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