Investigating Substantia Nigra Damage using Fully Automated Segmentation of Neuromelanin MRI in Early Parkinson’s Disease
Objective: Development of reliable imaging biomarkers of dopaminergic cell neurodegeneration is crucial to facilitate therapeutic drug trials in Parkinson's disease (PD). Neuromelanin-sensitive (NM) MRI techniques…Thalamic nuclei volumes and intrinsic thalamic network in motor subtype in Parkinson’s disease
Objective: The aim of this study is to investigate the alterations of thalamic nuclei volumes and intrinsic thalamic network in patients with de-novo PD according…Impairment of the mesocortical dopamine system in Parkinson’s disease patients with freezing of gait in a multimodal imaging approach
Objective: To investigate the involvement of dopaminergic systems in Parkinson’s disease (PD) patients with freezing of gait (FOG) using a multimodal assessment involving 18 F-DOPA-PET…Bilateral double beta peaks in a PD patient with STN electrodes
Objective: We aimed to record LFPs of the subthalamic nucleus (STN) from a PD patient with a new implantable pulse generator (IPG), which is capable…Effects of Long-Term Treatment with Fluvoxamine on Non-Motor Symptoms and Neurogenesis in an Early Post-Natal Stress Rat Model of Parkinson’s Disease
Objective: To look at the long-term effects of Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), and its neuroprotection potential in a rat model of Parkinson’s…PRO-PARK study: Is there an association between PROfessional occupation and PARKinson´s disease?
Objective: To asses if there is an association between professional occupation and Parkinson´s disease (PD). Background: Some personality features including rigidity, less novelty-seeking, and less…Quality of Life in Parkinson´s Disease Patients with Depression and Impulsive-compulsive Behaviors
Objective: To analyze quality of life (QoL) in Parkinson´s disease (PD) patients regarding to have depression, impulsive-compulsive behaviors (ICBs), or both. Background: Depression and ICBs are…Long-term effects of air pollution on the risk of Parkinson’s disease
Objective: We aimed to investigate the association between air pollution, including fine particulate matter (particles 2.5 mm in diameter, or PM2.5), and the risk of…Psychiatric comorbidities in Young Onset Parkinson’s disease
Objective: The study aims at exploring psychiatric comorbities;namely;anxiety,depression and impulse control disorders(ICD) and their inter relationship in a large cohort of Young onset PD(YOPD)patients. Background:…Safety and efficacy of istradefylline, an adenosine A2A receptor antagonist, as a function of baseline dyskinesia (BL-dyskinesia) in Parkinson’s disease (PD): A pooled analysis of 4 studies
Objective: To evaluate the effect of BL-dyskinesia on the efficacy and safety of istradefylline in 4 randomized, placebo-controlled, double-blind, phase 2b/3 trials. Background: Istradefylline, a…
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