Quantitative Assessment of X-linked Dystonia-Parkinsonism Using Wearable Sensing Technology
Objective: To create a quantitative, objective framework for assessing combined dystonia parkinsonism using kinematic data from wearable sensors combined with machine learning (ML), enabling clinician-independent…Impact of Striatal Degeneration on Clinical Phenotype in Idiopathic Normal Pressure Hydrocephalus: A Comparative Analysis
Objective: To compare the clinical phenotype between patients with normal and abnormal dopamine transporter scan (DaTscan) in probable and definite idiopathic normal pressure hydrocephalus (iNPH).…Managing Cognitive Decline in Vascular Dementia with Associated Parkinsonism
Objective: The intersection of vascular dementia (VaD) and secondary parkinsonism presents a complex therapeutic conundrum, particularly in geriatric populations. This study aims to elucidate the…Abstract: Trends in Movement Disorders related death in the United States from 1999 to 2020
Objective: We aimed to analyze the mortality and prevalence of movement disorders in the United States from 1999 to 2020 to compare disparities among various…Effects of ectopic dopamine D2 autoregulation of raphe-striatal projecting neurons on established L-DOPA-mediated behaviors in a hemiparkinsonian rat model
Objective: Levodopa (LD) is the standard treatment for Parkinson’s Disease (PD) despite risk of LD-induced dyskinesia (LID) development within a decade of treatment. Serotonergic (5-HT)…Automated Imaging Differentiation of Parkinsonism (AIDP): A Prospective 21-site Trial within the Parkinson’s Study Group
Objective: To prospectively test the performance of Automated Imaging Differentiation of Parkinsonism (AIDP), a machine learning based diagnostic biomarker software for Parkinson’s disease (PD), multiple system atrophy Parkinsonian…KMT2B-Related Dystonia And DBS: Tertiary Center Experience
Objective: This study aims to evaluate the functional outcomes and effectiveness of deep brain stimulation (DBS) in patients with genetic dystonia secondary to a KMT2B …Determining and Leveraging Local Ancestry to Assess Individual-Level Risk: from the Global Parkinson’s Genetics Program
Objective: We develop a scalable pipeline leveraging existing tools to determine local ancestry for all individuals in the Global Parkinson’s Genetics Program (GP2), aiming to…The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson’s Disease.
Objective: To evaluate the possible neuroprotective effects of mitochondrial NLRP3 inflammasome inhibition in a 6-hydroxydopamine mouse model of Parkinson's Disease. Background: Overactivation of brain immune…Wilson’s Disease About A Complex Case
Objective: We report the case of a patient who experienced diagnostic wavering. Background: Wilson disease is a rare disease. Cases in Africa is even rarer.…
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