Preclinical Studies: Investigating Serum-Based Exosomal miRNAs in Prodromal Drug-Induced Parkinson’s Disease
Objective: This work aims to elucidate the identification of homologs of miRNAs in a pronormal stage of Parkinson`s disease. Background: Parkinson's disease (PD) is defined…Parkinsonism after Internal Globus Pallidus Deep Brain Stimulation in Dystonia
Objective: To evaluate the frequency and predictors of parkinsonism after GPi-DBS in dystonia; to describe the clinical characteristics and stimulation changes performed to improve parkinsonism.…Parkinsonism in combined Fragile X and XYY Syndromes: A Case Report
Objective: We describe an unusual case of parkinsonism in a 45-year-old male with Fragile X syndrome and XYY syndrome. Background: Fragile X syndrome (FXS) is…GBA Mutation Profile in Parkinson’s Disease: Insights from a Movement Disorders Center in Brazil
Objective: To identify the prevalence of pathogenic variants of the GBA1 mutation among patients with parkinsonism who have undergone genetic testing. Background: GBA gene encodes…Comprehensive Strategy for Increasing Clinical Research Participation of Black and Hispanic Patients with Parkinsonism
Objective: To implement and test a multidimensional strategy for increasing racial and ethnic diversity in parkinsonism research. Background: Diversity in research participation is critical for…Catalan MSA Registry (CMSAR): Applying new Clinical Criteria and Biomarkers for Increasing Diagnostic Accuracy, is New Better?
Objective: To reassess the CMSAR and determine if new criteria and new biomarkers can enhance diagnostic accuracy. Background: The CMSAR, conducted between 2015 and 2019,…Accuracy of Clinical features for Substantia Nigra Hypopigmentation and Cortical Lewy Body Presence in the Oldest-Old: The 90+ Study
Objective: To improve clinical diagnostic accuracy of Lewy Body Dementia (LBD), we assessed if frontal release signs are a useful screening tool for cortical Lewy…Mixed Brain Pathology in Neurodegenerative Parkinsonism and Dementia
Objective: To assess the presence of mixed neurodegenerative pathology and its proportion in the prospective cohort of patients treated for any phenotype of neurodegenerative parkinsonism,…Cognitive Side Effects to Initial Levodopa Exposure as a “Red Flag”: A Retrospective Study
Objective: To assess if presence of cognitive side effects during an initial levodopa trial suggests the ultimate diagnosis of atypical Parkinson (APD) vs Parkinson disease…Brainstem Monoaminergic Degeneration, Cognition, and Autonomic Symptom Progression in Early Parkinson’s Disease
Objective: In this study, we aimed to investigate the association between brainstem monoaminergic nuclear degeneration, particularly the serotonergic raphe and noradrenergic locus coeruleus, and cognitive…
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