Identification of ZYIL1, a novel NLR family pyrin domain containing 3 protein inhibitor: a potential disease modifier in Parkinson’s disorder
Objective: Identification and evaluation of the potential of a novel NLR family pyrin domain containing 3 (NLRP3) inflammasome inhibitor (ZYIL1) as a Parkinson’s disease (PD)…Motor evaluation of Parkinson disease and Vascular parkinsonism using the TUG encephalog application
Objective: We aimed to compare gait and parkinsonian features between PD patients, VP patients and PD patients with Vascular component (PDVC) using a smartphone-based motion…Diagnostic challenges in a case of SLC6A3-related Dopamine Transporter Deficiency Syndrome
Objective: We report a case presenting with symptoms of classical Dopamine Transporter Deficiency Syndrome (DTDS) with negative results on initial whole-exome sequencing (WES), but eventually…To stimulate or not to stimulate? Bilateral subthalamic (STN) Deep Brain Stimulation (DBS) in cases of young-onset parkinsonism with mitochondrial dysfunction induced neurodegeneration.
Objective: To describe two cases of young-onset parkinsonism (YOP; case 1 with mitochondrial membrane protein associated neurodegeneration (MPAN) due to a heterozygous mutation in C19orf12;…Prodromal stage early biomarkers in Parkinson’s disease and parkinsonism in Uzbek nationality
Objective: Evaluation of prodromal stage biomarkers in Parkinson's disease and their role in disease progression Background: From a pathophysiological point of view, PD is characterized…Iron deposition and volume change of deep grey matter nuclei in PARK14 by Quantitative Susceptibility Mapping
Objective: PLA2G6 is the causative gene for autosomal recessive Dystonia-Parkinsonism (PARK14). The aim of this study was to explore the characteristics of iron deposition within…The correlation between genetic factors and freezing of gait in patients with Parkinson’s disease
Objective: We aimed to evaluate the association of six selected polymorphism of DRD2, ANKK1, and COMT genes with the occurrence of freeying of gate (FOG),…In vivo synaptic density in parkinsonism
Objective: To provide first evidence of in vivo binding properties of the [18F]SynVesT-1 tracer (aka [18F]-SDM-8) for the quantification of synaptic density loss in a…Safety, Target Engagement and Effects of Bosutinib in Dementia with Lewy Bodies
Objective: To investigate the safety, biomarkers effects and determine the lowest effective dose of Bosutinibin Dementia with Lewy Bodies (DLB) Background: The effects of bosutinib,…Advance Care Planning and Parkinson’s disease: patient knowledge assessment
Objective: Evaluate disease knowledge in patients with Parkinson’s disease in an Advance Care Planning (ACP) clinic. Background: Poor disease knowledge has been associated with misconceptions…
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