Presynaptic dopamine compartmentalization defects initiate auxilin-mediated parkinsonism
Objective: To evaluate the pathogenic mechanisms for auxilin-mediated Parkinson’s disease (PD). Background: Auxilin participates in uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV)…Protective effects of Hibiscus sabdariffa extracts in 6-hydroxydopamine-lesioned parkinsonism.
Objective: The therapeutic effects of Hibiscus sabdariffa (HS) were investigated in parkinsonism rats induced by 6-hydroxydopamine (6-OHDA). Background: The oxidative stress is an important component…The Efficacy of a Remote Cognitive Remediation Therapy (CRT) Program on Parkinson’s Disease
Objective: To determine the feasibility and impact of remote cognitive remediation therapy (CRT) on cognitive function and quality of life (QOL) in patients with Parkinson’s…Diagnostic value of striatal [18F]-FP-DTBZ PET in Parkinson’s disease
Objective: To detect the difference of dopaminergic integrity between PDs and healthy controls (HC) using [18F]-FP-DTBZ PET in vivo and to obtain the diagnostic value…Amelioration of Levodopa-induced Dyskinesias using Genetic Silencing of Striatal CaV1.3 in Parkinsonian Rats: Impact of Sex and Advancing Age
Objective: To advance understanding of striatal CaV1.3 (cacna1d) channel silencing as a therapeutic approach to reduce levodopa-induced dyskinesias (LID), a side effect of long-term escalating…Activity and sleep associated with changes in glymphatic imaging-markers in Parkinson Disease patients enrolled in 3-month exercise program
Objective: To investigate whether intensity of activity and quality of sleep during a 3-month exercise program for patients with Parkinson Disease (PD) are associated with…The role of Parkinson Nurses for personalizing care in Parkinson’s Disease: a systematic review and meta-analysis
Objective: To identify the various roles and functions that Parkinson Nurses (PNs) may hold for personalized care of Patients with Parkinson’s (PwPs). Providing a systematic…Sleep Disorders in Normotensive Hydrocephalus
Objective: Objective of the work was to study the prevalence of sleep disorders, Rem Sleep Behaviour Disorder (RBD) and obstructive sleep apnea (OSA) in patients with NPH.…The correlation between genetic factors and freezing of gait in patients with Parkinson’s disease
Objective: We aimed to evaluate the association of six selected polymorphism of DRD2, ANKK1, and COMT genes with the occurrence of freeying of gate (FOG),…In vivo synaptic density in parkinsonism
Objective: To provide first evidence of in vivo binding properties of the [18F]SynVesT-1 tracer (aka [18F]-SDM-8) for the quantification of synaptic density loss in a…
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