Brain first-body first: is the dat-scan useful?
Objective: The purpose of this study is to evaluate possible differences in the DAT-SCAN ratios in patients with and without dysautonomia and RBD at diagnosis.…Cognitive function in Parkinson’s disease: associations with perivascular space in basal ganglia
Objective: This study investigated the association of enlarged perivascular space (EPVS) and white matter hyperintensity (WMH) with cognitive impairment in Parkinson's disease (PD). Background: Cognitive…The prevalence of delirium and subsequent outcomes in inpatients with Parkinson’s disease
Objective: To report delirium prevalence in hospitalised Parkinson’s disease (PD) participants compared to older adults and examine the association with mortality in a prospective study.…People with Parkinson’s Disease present compensatory cortical activity patterns during split-belt treadmill walking, regardless of leg or disease side dominance.
Objective: To study the effects of Parkinson’s Disease (PD) on cortical activity during split-belt (SB) walking compared to tied-belt (TB) walking, and the impact of…A novel, population-specific PINK1 p.F385S loss of function mutation in an Indian family with Parkinson’s disease
Objective: To understand the molecular function of a novel missense PINK1 variant identified in an Indian family with Parkinson’s disease (PD). Background: The molecular understanding…Neurite Orientation Dispersion and Density Imaging and Diffusion Kurtosis Imaging in Brainstem Nuclei for Subtypes of Parkinson’s Disease
Objective: We utilized neurite orientation dispersion and density imaging (NODDI) along with diffusion tensor and kurtosis imaging (DTI/DKI) to assess brainstem nuclei in Parkinson’s disease…Home-based titration with Duodenal infusion of Levodopa in People with Parkinson’s disease: an observational feasibility study
Objective: Primary objectives were to assess the feasibility and safety of LCIG home titration with use of telemedicine-assisted (TM) technology, and patient/caregivers satisfaction. Secondly, to…Novel application of the Timed Up and Go Scale as a reliable tool to measure functional improvement and fall prevention after inpatient Parkinson’s Disease specific rehabilitation for advanced stages of PD
Objective: To determine whether the “Timed Up and Go” (TUG) scale can be effectively utilized in patients with advanced Parkinson’s disease (PD) as an outcome…LRRK2 Inhibition by BIIB122/DNL151 Demonstrates Robust Target and Lysosomal Engagement: Pharmacokinetics, Pharmacodynamics and Safety in Phase 1 and Phase 1b Studies in Healthy and Parkinson’s Participants
Objective: To characterize the pharmacokinetics (PK), pharmacodynamics, safety, and exposure-response (E-R) relationships of BIIB122/DNL151 to inform on clinical dose selection. Background: Increased LRRK2 kinase activity…Olfactory dysfunction and neuropsychiatric manifestations in early drug-naïve Parkinson’s disease
Objective: To determine the severity of various neuropsychiatric disturbances in drug-naïve Parkinson’s disease (PD) patients with (PD-OD) and without olfactory dysfunction (PD-NOD) compared to healthy…
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