A motor-cognitive intervention impacts daily-living gait and activity in Parkinson’s disease fallers differently than a motor intervention: analysis using a machine learning approach
Objective: Applying machine learning (ML) to identify if there were clusters of daily-living gait and physical activity measures that differed among responders to the two…Transauricular Vagus Nerve Stimulation (taVNS) for mild to moderate Parkinson’s Disease (PD)
Objective: We evaluated feasibility, safety, and preliminary efficacy of taVNS for motor and non-motor symptoms in mild to moderate PD. Background: Neuronal loss in the…Temporal Dynamic Alterations of Regional Homogeneity in Parkinson’s disease: A Resting-State fMRI Study
Objective: We aimed to test the differences of dynamic regional homogeneity (dReHo) between PD patients and healthy controls (HCs), and explore whether dReHo can be…To Prescribe or Not to Prescribe: Assessing the impact of Parkinson’s nurse prescribers
Objective: Within the UK, after successful completion of a formally recognised programme Parkinson’s Nurse Specialists (PNS) can act as independent prescribers, and as part of…Dopamine-independent cortical disinhibition in Parkinson’s disease
Objective: To test the hypothesis that cortical disinhibition in Parkinson's disease is a dopamine-independent process. Background: Motor cortex alterations in Parkinson's disease are classically considered…Oscillatory activity of pause-burst STN neurons shows an association with motor symptoms of Parkinson’s disease
Objective: Here we aimed to investigate heterogeneity in the neuronal activity within the subthalamic nucleus (STN) to search the association between oscillatory activity and motor…Assessment of microstructural changes associated with levodopa-induced dyskinesia in hemiparkinsonian rodents
Objective: To assess white matter (WM) microstructural integrity changes in pre-clinical models of Parkinson’s disease (PD) with levodopa-induced dyskinesia (LID). Background: PD is a neurodegenerative…Investigating the use of DAT-SPECT as an enrichment biomarker to determine eligibility for the phase 2 clinical trial PASADENA
Objective: Evaluate dopaminergic imaging DAT-SPECT as an enrichment strategy to avoid inclusion of participants with scans without evidence of dopaminergic deficit (SWEDD) in a Phase…Long-term follow-up of subthalamic nucleus deep brain stimulation for Parkinson’s disease: survival and disability milestones
Objective: To characterize retrospectively the long-term survival of 109 PD patients after 8 years of STN-DBS and to identify the incidence of the milestones of…Cortical beta activity in doorway-provoked motor blocks in Parkinson’s disease
Objective: To investigate cortical activity of doorway-provoked motor blocks (MB) during pedalling in Parkinson’s disease (PD). Background: Freezing of gait (FOG) is common in PD…
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