GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Association Between Antiepileptic Drugs and Subsequent Parkinson’s Disease in East London
Objective: To investigate the association between antiepileptic drugs (AEDs) prescription and subsequent Parkinson’s disease (PD). Background: Recent observational studies have highlighted an association between epilepsy…Diagnostic accuracy of susceptibility map-weighted MRI for discriminating tremor-dominant Parkinson’s disease and essential tremor
Objective: We investigated the diagnostic accuracy of nigrosome using susceptibility map-weighted imaging (SMwI) in distinguishing tremor-dominant Parkinson's disease (PD) and essential tremor (ET). Background: Tremor is…Correlation of clinical profile of Parkinsonism with molecular imaging
Objective: CORRELATION OF CLINICAL PROFILE OF PARKINSONISM WITH MOLECULAR IMAGING (TRODAT AND PET-CT BRAIN) Background: The current study aims to establish the role of Molecular…Free-viewing eye tracking in Parkinson’s disease and correlation with clinical features
Objective: The objective of our study is to determine whether differences in saccade amplitude/velocity in combination with pupillary dynamics and blink rate in a cohort…Addition contact with 10 Hz stimulation in the STN may improve stimulation-induced cognitive disturbances
Objective: This case report demonstrates improvement of cognition by adding low-frequency stimulation in the ventral subthalamic nucleus (STN). Background: Deep brain stimulation (DBS) targeting the…Differences by sex in patients with Parkinson’s disease (PD) and impulse control disorder (ICD) in the Mexican population.
Objective: To identify motor, cognitive and overall ICDs differences by sex in Mexican patients with PD and ICDs Background: ICDs are characterized by a failure…Experience of Quality of Life in German Persons living with Parkinson’s Disease: A Qualitative Exploration
Objective: It seems essential to understand how people with Parkinson´s disease (PwPD) experience quality of life (QoL) and to which domains they assign particular importance.…Patterned alternating-coloured strips for freezing of gait – Novel solution for a disabling symptom.
Objective: To evaluate a novel method of visual cueing using patterned alternating-coloured strips made of electrical tape for freezing of gait. Background: Freezing of gait…A new synchronization method between inertial signals and local field potentials
Objective: This study aims to define a method to synchronize inertial signals recorded using wearable sensors and local field potentials recorded by the neurostimulator implanted…
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