LRRK2 PROTAC® degrader molecules induce robust biomarker responses in preclinical in vivo pharmacology studies following acute and chronic oral dosing
Objective: Report on the non-clinical in vivo pharmacokinetic and pharmacodynamic biomarker response to PROteolysis TArgeting Chimera (PROTAC®) molecules designed to induce degradation of leucine rich…Microbiota and Gastrointestinal Manifestations of Parkinson’s Disease with Arabic Translation of Gastrointestinal Dysfunction Scale
Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut…An European-Canadian multinational evaluation of access to care in Parkinson disease: a patient perspective
Objective: To provide a multi-national perspective of people with Parkinson disease (PwPD) on access to healthcare and the impact of the COVID-19 pandemic on those…ParkProReakt Study Protocol – A randomized controlled trial to evaluate a proactive approach to health care in Parkinson’s disease
Objective: To implement and evaluate a novel care model for people with Parkinson’s Disease (PD), based on the following principles: proactive, person-centered, and digital (cf.…Distinct striatal connectivity patterns in patients with Parkinson’s disease with and without urinary symptoms
Objective: To investigate the potential effect of urinary symptoms on the regional striatal functional connectivity (FC) in a cohort of drug-naïve PD patients applying a…Genetic profile of early-onset Parkinson’s Disease patients at a movement disorders center in Brazil
Objective: This study aimed to identify the genetic landscape of early-onset Parkinson’s Disease (EOPD) in a cohort from a referral center in Brazil. Background: Parkinson’s…The effect of levodopa on the blood activity of calpains in patients with Parkinson’s disease
Objective: To evaluate the effect of levodopa on the blood activity of calpains in patients with PD Background: Parkinson's disease (PD) is a chronic progressive…Dyspnea and quality of life in Parkinson’s: a mixed methods study
Objective: This study aimed to explore dyspnea experiences in people living with Parkinson’s PlwP who are walking independently. Background: Dyspnea is one of the non-motor…The effect of subthalamic therapeutic deep brain stimulation on pallidal and cortical activity in Parkinson’s disease
Objective: To evaluate the effect of subthalamic (STN) deep brain stimulation (DBS) on the globus pallidus (GP) and motor cortex Background: Progressive neuronal loss in…Unveiling the role of subthalamic nucleus stimulation on freezing of gait in Parkinson disease using wearable sensors
Objective: Objectives: To determine whether Deep Brain Stimulation on the Subthalamic nucleus (STN-DBS) is responsible for post-surgery de novo On-State Freezing-of-Gait (FOG) in PD patients, and…
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