DNA Methylation is associated with gene expression changes in sporadic Parkinson Disease in the PPMI cohort.
Objective: To compare baseline whole blood DNA methylation in unmedicated sporadic Parkinson Disease (sPD) and healthy control (HC) participants from PPMI. To evaluate whole blood…Genetic diagnosis of parkinsonian phenotype of Machado Joseph Diseasep (SCA-3) presenting with dopa induced dyskinesia
Objective: We report a rare type IV parkinsonian phenotype of MJD having a rare genetic mutation. SCA type 3 (SCA3), also known as Machado-Joseph disease…Сlinical neurological features of diabetic and non-diabetic patients with Parkinson’s disease.
Objective: In the last decade, attention has been focused on the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system, insulin in…Longitudinal recordings of subthalamic local field potentials show intra-subject consistency of beta-based physiomarkers in Parkinson’s Disease
Objective: To investigate long-term consistency of spectral data features extracted from local field potential (LFP) recordings of the subthalamic nucleus (STN) in Parkinson’s disease (PD)…Text entry as a digital outcome in Parkinson’s disease patients (TEXT-PD): results from two exploratory studies
Objective: To evaluate the feasibility and psychometric properties of text entry (TE) and touch metrics as digital outcomes for PD patients. Background: TE on smartphones…Evaluation of cases of psychosis from opicapone safety data
Objective: Investigate the likelihood of association of Opicapone (OPC) with psychotic symptoms (other than hallucinations). Background: Neuropsychiatric symptoms frequently occur in Parkinson’s Disease (PD) patients,…Axial impairment and bradykinesia are related to increased CSF sTREM2, a neuroinflammation biomarker, in Parkinson’s disease
Objective: To explore the association between Parkinson’s disease (PD) motor symptoms and CSF biomarkers for neuroinflammation and neurodegeneration. Background: Previous in vivo and post mortem…Diabetes impact on nigrostriatal vulnerability in Parkinson’s Disease
Objective: aim of the study was to investigate whether diabetes mellitus influences nigrostriatal dopaminergic vulnerability in drug-naïve patients with early-stage Parkinson’s Disease (PD). Background: recently,…Combined GWAS of Dementia with Lewy Bodies, REM-Sleep Behavior Disorder, Parkinson’s Disease and Alzheimer’s Disease
Objective: To identify genetic variants that are either shared between or specific for Dementia with Lewy Bodies (DLB), REM Behavior Disorder (RBD), Parkinson’s disease (PD)…Sexual health and sleep quality in women living with Parkinson’s disease: are we neglecting that?
Objective: To investigate the relationship between sexual health and sleep quality in PD. Background: Sexual dysfunction (SD) is a common yet under-reported, non-motor symptom (NMS)…
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