Reductions in OFF time with ND0612 for patients with Parkinson’s disease experiencing motor fluctuations: Responder-analysis from an open-label Phase 2 study
Objective: Evaluate the efficacy of subcutaneous levodopa/carbidopa infusion with investigational ND0612 in reducing OFF time in people with Parkinson’s disease (PwP) experiencing motor fluctuations. Background:…Development of potent, orally bioavailable, and highly selective LRRK2 PROTAC® degrader molecules as potential disease modifying therapeutics for Parkinson’s disease
Objective: Report on the pharmacological characteristics of small molecule PROteolysis TArgeting Chimera (PROTAC) molecules designed to induce degradation of leucine rich repeat kinase 2 (LRRK2)…Deep Brain Stimulation in Parkinson’s Disease: real-world outcomes at a single centre
Objective: To describe the clinical outcomes in PD patients following DBS and analyse whether certain demographic and clinical factors are associated with poor outcomes. Background:…Correlation between rem sleep disorders and neurocognitive defects in patients with parkinson´s disease
Objective: The objective of the following study was to verify the correlation between cognitive disordersand REM sleep disorders. Background: REM sleep disorder affect a large…The effects of dopaminergic treatment on interhemispheric disinhibition and bradykinesia asymmetry in Parkinson’s disease
Objective: to investigate whether dopaminergic therapy modulates IHI and bradykinesia asymmetry in PD. Background: previous evidence demonstrated a reduced interhemispheric inhibition (IHI) in Parkinson’s disease…Chronic sensorimotor cortex sensing using permanently implanted subgaleal leads in a patient receiving deep brain stimulation for Parkinson’s disease
Objective: Assess the feasibility of chronic subgaleal cortical sensing using two distinct recording leads. Background: Pathological oscillatory activity in cortico-basal ganglia (BG) circuits is implicated…Assessing Gait Disturbances in Parkinson’s Disease Using Multi-Spectral Diffusion Weighted Imaging
Objective: We aimed to use diffusion MRI quantitative maps as an objective, non-invasive measure to assess for gait disturbances in Parkinson’s Disease (PD). Background: PD…Gender inequities in people living with PD and their caregivers’ burden in Mexican population
Objective: To compare motor and non-motor dysfunction, quality of life (QoL), and caregiver burden (CB) between women and men living with PD, and its relationship…Combined approach in the diagnostic of Parkinson’s disease
Objective: Our aim was to develop and scientifically substantiate set of criteria for early(preclinical) diagnosis of neurodegenerative disorders with the assessment of a number of…A novel motor-learning based dysphagia treatment approach in Parkinson’s disease
Objective: This pilot study tested the effectiveness of a novel motor learning and exercise principle-based dysphagia treatment approach in PD. Background: Dysphagia occurs in 90% percent…
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