PARKIN gene replacement by AAV-mediated gene delivery as a therapeutic modality for PARKIN-deficient early-onset familial Parkinson’s disease
Objective: Evaluate PARKIN gene replacement by adeno-associated virus (AAV) vector as a therapeutic modality in relevant disease models of early-onset Parkinson’s Disease (EOPD). Background: Biallelic…Mapping the distribution of neurotransmitters to resting-state functional connectivity in patients with Parkinson’s disease
Objective: To examine the associations between functional connectivity (FC), as measured by resting-state functional magnetic resonance imaging (rs-fMRI), and the spatial distribution of dopamine and…Comparing 18F-AV133 VMAT2 PET and DATscan as Markers of Parkinson’s Disease Severity and Progression
Objective: Compare VMAT2 PET signal with DATscan at baseline and over time, and evaluate their correlations with MDS-UPDRS III. Background: DATscan is a Parkinson’s disease…Morphology and Functional Connectivity of the Basolateral Amygdala and Rapid Eye Movement Sleep Behavior Disorder
Objective: To determine the correlation of BLA morphology and functional connectivity (FC) with severity of RBD. Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD)…Characterization of a Novel alpha-synuclein PET radiotracer, [18F]C05-05, in a PPMI Sub-study
Objective: Characterization of the PET radiotracer, [18F]C05-05, in the PPMI Study Background: Validation of imaging biomarkers in Parkinson disease (PD) is a major objective of…Raynaud’s Phenomenon and Diaphoresis During Initial Programming of Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease: A Case Report
Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor symptoms in advanced Parkinson's disease (PD). However, autonomic side…The impact of Deep Brain Stimulation for Parkinson’s disease on Quality of Life
Objective: To evaluate the long-term outcomes in Quality of Life (QoL) for patients with Parkinson’s disease (PwP) enrolled in a global, real-world device registry for…Using LEAD-DBS to Identify the Optimal DBS Electrode in the Abbott Infinity System
Objective: To determine whether the optimal electrode contact selected in Abbott deep brain stimulation (DBS) leads is the same using conventional versus image-guided programming (LEAD-DBS…Tension Pneumocephalus as an acute complication of STN-DBS surgery
Objective: To describe a rare complication of Deep Brain Stimulation (DBS). Background: DBS is a surgical treatment for Parkinson´s Disease (PD). Among the possible surgical…Efficiency of AI-Based Service for Screening Diagnostics of Parkinson’s Disease (Brainphone Project)
Objective: The aim of the clinical study was the assessment of efficiency of the screening diagnositics method for Parkinson's disease (PD) by voice using AI-based…
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