Inflammatory microglial and astroglial phenotype associated with pathological alpha-synuclein inclusions in the substantia nigra
Objective: To characterize neuroinflammatory gene expression in microglia and astrocytes associated with early alpha-synuclein (a-syn) inclusion formation. Background: Parkinson’s disease (PD) is characterized by alpha-synuclein…Protective mechanism of melatonin via heat shock protein in the MPP+-induced in vitro Parkinson’s disease model
Objective: The objective of this study was to investigate the protective properties of melatonin in an in vitro Parkinson’s disease (PD) model, especially focusing on…Month 24 results of a virtual longitudinal, observational study of Parkinson’s disease: The AT-HOME PD cohort
Objective: To describe the change in characteristics of Parkinson’s disease (PD) clinical trial participants over 24 months following trial participation in a remote, longitudinal observational…Examining the sex differences in the prevalence and incidence of Parkinson disease
Objective: The objective of this meta-analysis was to examine the male-to-female (M/F) incidence and prevalence of Parkinson disease. Background: Parkinson disease (PD) is a major…Novel bi-allelic variants in FBXO7 in a family with young-onset typical Parkinson’s disease
Objective: To describe the case of two brothers affected by typical young-onset Parkinson’s disease (PD), carrying novel compound heterozygous variants in FBXO7. Background: Bi-allelic mutations…Prevalence, clinical and neuropsychiatric aspects of Sleep Disorders in Parkinson’s disease: a meta-analysis
Objective: The present meta-analysis aims to provide a reliable estimate of the prevalence and associated clinical and neuropsychiatric aspects of the most frequent sleep disorders…Closing the gap: Increasing access to genetic testing and counseling for Hispanics through PD research
Objective: To report preliminary genetic findings of Hispanic participants from the PD GENEration Registry and GEN-EP Latino study. Background: The incidence of Parkinson disease across…Performance of Parkinson´s disease cognitive scale rating scale (PD-CRS) after 2 years Subthalamic nucleus deep brain stimulation. Comparison with Mattis Dementia Rating Scale (MDRS) and Mini-Mental State Examination (MMSE)
Objective: To study the performance of PD-CRS before and 2 years after STN-DBS and compare their results with other recognized cognitive scales. Background: Parkinson´s disease…Diagnostic Utility of I123-FP-CIT Single Photon Emission Computed Tomography for Patients with Clinically Uncertain Parkinsonian Syndrome
Objective: This study investigated the impact of I123-FP-CIT single photon emission computed tomography (SPECT) for the diagnosis of patients with clinically uncertain parkinsonian syndrome (CUPS)…DNA methylation differs between idiopathic Parkinson Disease and Healthy Control subjects in the Parkinson’s Progression Marker Initiative (PPMI) cohort
Objective: Compare baseline whole blood DNA methylation in unmedicated idiopathic Parkinson's Disease (iPD) and healthy control (HC) participants from PPMI Background: Epigenetic mechanisms like DNA…
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