Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control
Objective: We report clinical outcomes associated with the use of Deep Brain Stimulation (DBS) systems capable of directionality and Multiple Independent Current Control (MICC). Background:…Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up
Objective: To image progression of intestinal dysfunction, cardiac sympathetic denervation, and dopaminergic nigrostriatal damage in patients with isolated REM sleep behaviour disorder (iRBD). Background: A…Measuring what matters in Parkinson’s disease – validating real-world digital mobility outcomes for widespread adoption
Objective: To validate and support widespread adoption of real-world digital mobility outcomes (DMOs) to monitor mobility performance, disease progression and predict falls in patients with…Relation of affective disorders and quality of life in the chronic pain of disease Parkinson’s patients
Objective: To study affective disorders and their impact on the quality of life in patients with PD and chronic pain syndrome. Background: Mechanisms of the…Inducing motor cortical plasticity in Parkinson’s Disease patients using subthalamic deep brain stimulation and repetitive transcranial magnetic stimulation
Objective: To investigate whether motor cortical plasticity can be induced in Parkinson’s disease (PD) patients by pairing subthalamic deep brain stimulation (STN-DBS) and repetitive transcranial…Clinical phenotype of non-manifesting carriers of mutations in the GBA and LRRK2 genes
Objective: To explore the influence of carrying mutations in both the GBA and LRRK2 genes (dual mutation carriers) on risk for future development of Parkinson's…Outcomes after Deep Brain Stimulation (DBS) surgery in patients with young-onset Parkinson’s disease
Objective: To assess outcomes after deep brain stimulation (DBS) in patient with young-onset Parkinson’s disease (PD). Background: DBS is a surgical procedure which effectively treats…Blood biomarkers and their association with non-motor symptoms in early Parkinson’s Disease
Objective: To identify if baseline blood biomarkers are associated with non-motor symptoms in early PD. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with…Long-term safety of continuous levodopa/carbidopa infusion with ND0612: Data from patients who continued past one year in the BeyoND study
Objective: To report long-term safety and tolerability data from the ongoing BeyoND study (NCT02726386) for patients who continued treatment past the one-year primary endpoint. Background:…Comparison of Disease Progression in Patients with Brain-first versus Body-first Parkinson’s Disease
Objective: This study aimed to compare the clinical progression between brain-first and body-first PD groups using cardiac sympathetic denervation (CSD). Background: Brain-first and body-first Parkinson’s…
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