Influence of Disease Duration on Motor Progression in Parkinson’s Disease: A Longitudinal Cohort Study with Age at Onset Stratification and Sensitivity Analysis
Objective: To determine whether motor severity differences between EOPD ≤50 years and LOPD >50 years reflect age at onset (AAO)-related biology or disease duration, and…Kinematic Discriminative Component (KDC) a New Biomarker to Measure Parkinson’s Disease Severity
Objective: Develop and validate a video-based biomarker for Parkinson's disease (PD) that provides an interpretable, and clinically relevant measure of motor severity sensitive to medication,…The predictive value of the 18F-FDG PET-derived Parkinson’s disease Related Pattern for neurodegenerative disease progression in isolated REM Sleep Behavior Disorder
Objective: To determine whether baseline and longitudinal Parkinson’s disease–related pattern expression predicts conversion to Parkinson’s disease or dementia with Lewy bodies in idiopathic REM sleep…Describing Factors Associated with Progression in Parkinson’s Disease: A Retrospective Chart Review
Objective: To describe differences in sociodemographic and clinical profiles between patients with Parkinson’s disease (PD) who remain at Hoehn and Yahr (HY) stage 1–2 up…Responsiveness of a Smartphone-Based Sensor-Derived Composite Endpoint in a Phase 2b Study in Parkinson’s Disease (PD)
Objective: Development of a sensor-derived composite score (CS) for progression of motor symptoms in the LUMA study in PD. Background: LUMA (NCT05348785) is a randomized Phase 2b…Toward a Standardized Measure of Parkinson’s Disease Psychosis: Preliminary Inter-Rater Reliability of the MDS Parkinson’s Disease Psychosis Rating Scale (MDS-PDPRS)
Objective: To evaluate the inter-rater reliability (IRR) of the MDS-PDPRS in a pilot clinimetric cohort. Background: No validated outcome assessment exists to measure the functional…Microglial Inflammatory Signaling Mediates Neuroimmune Dysregulation And Behavioral Dysfunction in A Parkinson’s Disease Model
Objective: To determine whether M1 microglial signaling via FAM19A3, CHI3L1, and VILIP-1 contributes to neuroinflammation, neuronal degeneration, and behavioral dysfunction in a Parkinson’s disease, and…Impact of Hula on Balance Outcomes in Parkinson’s Disease
Objective: This study aims to determine the impact of a 12-week Hula program on balance in patients with Parkinson’s Disease (PD) and to investigate changes…Social Cognition in Patients with Parkinson’s Disease
Objective: We aimed to investigate social cognition in patients with Parkinson's disease (PD) using facial affect tasks of the Florida Affect Battery (FAB). Background: Patients with…Circadian Regulator REV-ERBα Drives Microglial Lipid Metabolic Reprogramming and Cognitive Impairment in Parkinson‘s Disease
Objective: To investigate the mechanisms by which sleep disturbance exacerbates motor and cognitive deficits in Parkinson’s disease (PD), and to determine how alterations in the…
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