Characterization of the pathogenic α-Synuclein variant p.V15A in Parkinson´s disease
Objective: To investigate functional alterations of the p.V15A variant in alpha-Synuclein (α-Syn) in Parkinson's disease (PD). Background: PD is marked by the loss of dopaminergic…The characterization of Parkinson’s disease related nociplastic pain based on the classification system
Objective: The characteristics of Parkinson’s disease (PD)-related nociplastic pain were evaluated by using various indicators including PD pain classification system (PD-PCS), King's Parkinson Disease Pain…Novel modifiers of heterozygous pathogenic Parkin variant penetrance in Parkinson’s disease
Objective: To identify novel genes and pathways acting as modifiers of pathogenic Parkin variant (PV) penetrance in affected compared to unaffected carriers of heterozygous Parkin PVs…A 16-week open-label study of the effects of treatment with pimavanserin on activities of daily living in subjects with Parkinson’s disease psychosis (PDP)
Objective: To examine the effects of pimavanserin on activities of daily living during treatment for Parkinson’s Disease psychosis. Background: Accurate assessment of disability associated with…Olfactory dysfunction as a predictor of the future development of parkinsonism in COVID patients
Objective: Olfactory dysfunction due to SARS-CoV-2 infection as a prodromal stage of PD. Background: Olfactory dysfunction due to SARS-CoV-2 disease can depend on the neuroinvasive properties…Bilateral subthalamic nucleus deep brain stimulation in Parkinson’s disease: preoperative predictors of speech worsening
Objective: To find preoperative predictive factors of short-term postoperative speech worsening in a large cohort of consecutive PD patients treated with bilateral STN-DBS. Background: Subthalamic…6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (F-DOPA) PET striatal binding patterns in patients with Parkinson’s Disease and Parkinson Plus Syndromes.
Objective: In this study we investigate striatal binding patterns in patients with Idiopathic Parkinson’s disease (IPD), compared to those with Parkinson Plus syndromes (PPS) versus…Detection and classification of GBA variants PD-related: is there sex unbalance?
Objective: This study aims to classify GBA variants detected in the Genetic Movement Disorders Laboratory (GMDL) of the Neurological Institute “Carlo Besta” in Milan over…Concealment of Parkinson’s Disease: Prevalence and Impact on Health and Quality of Life
Objective: (1) To explore the proportion and personal characteristics of patients who do not disclose their diagnosis of Parkinson's disease (PD) to their family, and…Effectiveness of speech therapy in patients with Parkinson’s disease – a randomized controlled trial
Objective: We aimed to assess the effectiveness of speech therapy on improving quality of life and speech quality in patients with Parkinson’s disease. Background: Although…
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