Genome-wide meta-analysis of Parkinson’s disease identifies a novel chromosomal 22 locus: findings from the COURAGE-PD consortium
Objective: The present study aims to conduct a meta-analysis in a large, diverse cohort to discover novel Parkinson’s disease (PD) loci and replicate previously reported…Lateral shifting from apomorphine subcutaneous infusion (ASI) to levodopa-carbidopa intestinal gel (LCIG) in the treatment of advanced idiopathic Parkinson’s disease (PD): Case series
Objective: To report our experience with transitioning from apomorphine subcutaneous infusion (ASI) to levodopa-carbidopa intestinal gel (LCIG) in two patients with advanced idiopathic Parkinson’s disease (PD). Background: Device-assisted…Modulation of the mesencephalic locomotor region activity during gait in parkinson’s disease patients
Objective: Deciphering the role of the MLR in gait and balance disorders in PD patients Background: Lesion or dysfunction of the MLR, including the Pedunculopontine…Substantia nigra dopaminergic neuron density in PD, PSP and MSA: An interim clinicopathological analysis
Objective: To investigate substantia nigra pars compacta (SNc) area together with dopaminergic neuron count and density in atypical parkinsonisms in relation to Parkinson’s disease (PD)…Comparison of different risk scores for Parkinson’s disease in a population-based 10-year study
Objective: To validate the “enhanced” PREDICT-PD algorithm in a longitudinal population-based cohort and compare its performance with other Parkinson's disease risk scores in identifying cases…Aerobic glycolysis regulates microglia-mediated neuroinflammation by promoting H3K9 lactylation in Parkinson’s disease
Objective: This study aims to investigate the role of histone lactylation in microglia-mediated neuroinflammation and dopaminergic (DA) neuronal damage in Parkinson’s disease (PD). Background: Augmented glycolysis induced by metabolic…miR-218-5p Regulates Microglia-mediated Neuroinflammation through Type I Interferon Response in Parkinson’s Disease
Objective: To explore the effect of miR-218-5p on microglia activation and dopaminergic neurons damage in mice model of Parkinson's disease(PD) and its potential mechanisms. Background:…The impact of thyroid disease on severity of motor symptoms in Croatian residents with de novo Parkinson’s disease
Objective: The goal of this study was to investigate the association between thyroid disease and severity of motor symptoms in Croatian residents with de novo…Descriptive case studies of patients in their fifth consecutive year of treatment with ND0612
Objective: To describe the long-term experience of three individual patients receiving subcutaneous (SC) levodopa/carbidopa infusion with ND0612 in an open-label clinical safety study. Background: ND0612…CCL5 promotes Th17 migrating into SNpc by promoting Th17 proportion increase and LFA-1 expression
Objective: To explore the specific pathway by which CCL5 induces Th17 cells migrating into substantia nigra pars compacta (SNpc) to aggravate Parkinson's disease (PD). Background:…
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