Cognition and Dementia in a Kenyan Parkinson’s Disease Cohort: A Sub-study of the TraPCAf Consortium
Objective: To describe Cognitive Impairment in the Kenyan PD TraPCAf cohort. Background: The epidemiology and natural history, including cognitive impairment (CI) of Parkinson's disease (PD)…Phase 1 Study of BT-409, a potent, selective, brain-penetrant, and oral small molecule inhibitor of NLRP3 in Healthy Volunteers and Adults with Parkinson’s disease
Objective: The objective of the study is to evaluate the safety, tolerability, and pharmacokinetics of BT-409. Background: Chronic activation of innate immune pathways has emerged…Body Weight Increases After DBS in Parkinson’s Disease but Not Essential Tremor
Objective: This retrospective longitudinal cohort study examined body weight trajectories surrounding unilateral and staged bilateral deep brain stimulation (DBS) across surgical targets in individuals with…Age-related characteristics of the clinical progression of Parkinson’s disease
Objective: To analysis of the rate of progression of the disease in PD according to the age of patients. Background: Although Parkinson's disease (PD) is…Lifestyle Changes After Parkinson’s Disease Diagnosis: Associations with Age, Sex, Disease Duration, and Self-Perceived Quality of Life
Objective: To assess lifestyle changes after PD diagnosis and their relationship with clinical and demographic factors. Background: In recent years, the management of Parkinson’s disease…Distinct Non-Motor Symptom Progression Subtypes in Parkinson’s Disease Identified Using a Data-Driven SuStaIn Model
Objective: To identify progression-oriented non-motor symptom subtypes in PD using a probabilistic Subtype and Stage Inference (SuStaIn) model applied to routinely available clinical assessments. Background:…Nutrition and Dietary Assessment as a Wellness Factor in Parkinson’s Disease and Related Disorders
Objective: To characterize nutrition and food related concerns identified during supportive care visits for individuals with Parkinson’s disease (PD) and related disorders. Background: Individuals with…Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease
Objective: To integrate mechanistic evidence delineating irisin mediated molecular pathways relevant to Parkinson’s disease (PD) pathogenesis and neuroprotection, focusing on α-syn clearance, autophagy–lysosomal function, mitochondrial…Effectiveness of Acupuncture for Parkinson’s Disease with Mild Cognitive Impairment A Randomized Clinical Trial
Objective: To evaluate the efficacy and safety of acupuncture for PD-MCI, and improve the credibility of acupuncture research evidence through employing a sham acupuncture device…Predicting Parkinson’s: Navigating Risk, Rights, and Regulation
Objective: This study explores the legal and ethical challenges surrounding predictive testing for Parkinson’s disease (PD), with a particular focus on its impact in employment,…
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