PPP2R5D Variants in Patients Diagnosed With Parkinson’s Disease. A Large‑Scale Multi‑Cohort Analysis
Objective: To identify individuals with rare pathogenic and potentially pathogenic variants of unknown significance (VUS) in PPP2R5D within large Parkinson’s disease (PD) cohorts, to characterize…Spatiotemporal Biomarkers of Early Postural Instability in Parkinson’s Disease: Implications for Early Intervention
Objective: To characterize spatiotemporal biomarkers derived from a quantitatively assessed pull test in patients with early Parkinson’s disease (PD). Background: The pull test is a…Smell as a Diagnostic Signature: Systematic Review and Meta-Analysis of UPSIT Accuracy in Distinguishing Parkinson’s Disease from Essential Tremor
Objective: To evaluate the diagnostic performance of the University of Pennsylvania Smell Identification Test (UPSIT) in differentiating Parkinson’s disease (PD) from essential tremor (ET) using…Effects of Modafinil on Motor and Non‑Motor Outcomes in Parkinson’s Disease: A Meta‑Analysis of Randomized, Placebo‑Controlled Trials
Objective: To determine the efficacy and safety of modafinil on motor and non-motor outcomes in Parkinson’s disease (PD) using evidence exclusively from randomized placebo‑controlled clinical…Evaluating the Stability of a Short Smell Test in the PREDICT-PD Cohort
Objective: To evaluate the stability of a 6-item smell test, in the context of a prodromal Parkinson’s (PD) cohort. Background: Short smell tests have been…12-week Aerobic Interval Training Induces Hemisphere-Specific Neuroprotection in Parkinson’s Disease: A Multimodal MRI, [18F]Fluorodopa PET/CT and BDNF Study
Objective: To investigate whether a 12-week aerobic interval training (AIT) can preserve subcortical brain structures in early Parkinson’s disease (PD) and whether these effects are…Phenoconversion from Rapid Eye Movement Sleep Behavior Disorder to Parkinson’s Disease: A multimodal Imaging Study
Objective: To elucidate the pathological progression from rapid eye movement sleep behavior disorder (RBD) to Parkinson’s disease (PD), we investigated tissue-level neurodegenerative changes using multimodal…Electrophysiological Evaluation of Visual Hallucination in Parkinson’s Disease Psychosis
Objective: Our understanding of the psychosis in Parkinson’s disease (PDPsy) is incomplete, and standard of care treatment with antipsychotics has its limitations. Neuroimaging and histopathology in PDPsy reveal that visual hallucinations (VHs), the hallmark of psychosis in PDPsy, arise…Parkinson’s Disease Duration at Total Knee Arthroplasty and 5-Year Vascular and Periprosthetic Outcomes: A Nationwide Matched Cohort Study
Objective: The objective of the study was to evaluate whether Parkinson's disease (PD) is associated with long-term risks of vascular events (cardiovascular and cerebrovascular) and…Considering Oral Health to Optimise the Potential for Current and Future Treatments in Parkinson’s Disease
Objective: To determine if the Oral Health Assessment Questionnaire (OHAQ) devised by 2 Parkinson’s Disease Nurse Advanced Practitioners (PDNAP) could facilitate a healthier mouth to…
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