Multi-Sequence MRI-Based Machine Learning Model for Differentiating Parkinson Disease (PD) from Multiple System Atrophy (MSA)
Objective: To develop a multi-sequence MRI-based machine learning model differentiating PD from MSA. Background: MRI protocols capable of distinguishing PD from MSA are greatly needed.…Gelsolin and Secretogranin-3 induce Parkinsonian features in rodent models.
Objective: To study the pathogenic potential of Gelsolin (GSN) and Secretogranin-3 (SCG3) in inducing Parkinsonian features. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…The Cats-and-Dogs Test Predicts Cognitive Impairment in Parkinson’s Disease in a Diverse Population
Objective: To determine whether the Cats-and-Dogs visuoperceptual task (CnD) predicts cognitive impairment (CI) in Parkinson’s disease (PD) in a diverse population in East London and…Postural Sway Frequencies in Isolated REM Sleep Behavior Disorder Might Indicate Subtle Motor Impairments as Prodromal Marker of Parkinson’s Disease
Objective: In this preliminary study, we aimed to compare postural sway between individuals with early, untreated Parkinson’s disease (PD), individuals with isolated REM sleep behavior…Clinical and Patient-Reported Outcomes in Patients With and Without Severe Bradykinesia According to Sensor Measurements
Objective: To explore clinical and patient-reported outcomes in patients with and without severe sensor-measured bradykinesia in patients with Parkinson’s disease (PD). Background: Parkinson's disease (PD)…Basal Ganglia Pathway Recruitment Determines Bidirectional Bradykinesia Modulation by DBS in Humans
Objective: Understanding the role of distinct basal ganglia pathways in DBS-elicited modulation of bradykinesia across its indications. Background: Opposing bidirectional effects of selective pathway stimulation…Optimizing Identification of Hyposmia for Parkinson’s Disease Risk Screening: Results from the Healthy Brain Aging Study
Objective: To evaluate whether questionnaire-based variables can identify individuals with Olfactory Dysfunction (OD), thereby supporting a targeted preselection approach for Parkinson’s Disease (PD) screening. Background:…When Presynaptic Stimulation is Not Enough: Severe Biphasic Dyskinesia on LECIG Reversed by Postsynaptic Apomorphine Rescue
Objective: To report an exceptional case of advanced Parkinson’s disease (PD) where levodopa/carbidopa/entacapone intestinal gel (LECIG) failed to provide adequate motor control, ultimately requiring a…Barriers to Disease-Modifying Clinical Trials in Parkinson’s Disease: A Survey of Clinicians and Researchers Involved in Clinical Trials
Objective: To assess clinician and researcher views on the integration of biomarkers and biological subtyping in PD trials and perceived barriers to recruitment and completion.…LRRK2 Mutation Spectrum and Association Study in a Multi-ethnic Cohort of Malaysian Parkinson’s Disease Patients
Objective: To systematically characterize the spectrum, haplotypes, and cumulative burden of LRRK2 variants and determine their associations with PD risk in the multi-ancestry Malaysian population.…
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