The Cleveland Clinic-Virtual Home Environment (CC-VHE): A Reliable Way to Trigger Freezing of Gait in Parkinson’s disease
Objective: To describe the development, safety, and efficacy of the Cleveland Clinic-Virtual Home Environment (CC-VHE) in provoking freezing of gait (FOG) in Parkinson’s disease (PD).…A personalized gait signature assay in Parkinson’s disease
Objective: To establish a personalized gait signature assay to inform on progression, phenotype and effects of intervention of gait abnormalities in PD. Background: Gait signatures…Health Disparity in Rural Southern California
Objective: To analyze the demographic and clinical characteristics of hispanic patients with Parkinson's disease in rural southern California Background: Parkinson’s disease (PD) is the second…The Role of Knowledgeable Informants in the Early Detection of Parkinson’s Disease
Objective: To investigate the reporting of changes observed by Knowledgeable Informants (KIs) and people with Parkinson’s disease (PwPD) prior to a Parkinson’s disease (PD) diagnosis.…Pesticide Exposure and Parkinson’s Disease Motor Subtype
Objective: The present study aims to investigate the link between Parkinson’s disease (PD) motor subtype and PD-relevant pesticide exposures. Background: PD is a neurodegenerative disorder…Clinical Characteristics of Parkinsons Disease and their Role in Differential Diagnosis
Objective: To study and systematize the clinical characteristics of Parkinson's disease (PD) and their role in differential diagnosis with other parkinsonian syndromes. Background: Parkinson’s disease…A Biomarker-Directed Approach to the Early Diagnosis of Parkinson’s Disease Using Artificial Intelligence and Machine Learning
Objective: The main purpose of this study was to assess how AI and ML methods integrate multiple biomarkers for diagnosing Parkinson’s Disease (PD) to improve…Establishing a Timeline of Non-Motor and Motor Symptoms Progression in Parkinson’s Disease Using a Sub-Chronic MPTP Mouse Model
Objective: Parkinson’s disease (PD) mouse model using 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was explored for pathological mechanisms driving non-motor symptoms (NMS). Aim was to map the behavioural changes…Unveiling the Molecular Mechanism of Polydatin in Ameliorating Parkinson’s Disease via the DRD2/CRYAB/NF-κB Axis in Astrocytes and Exploring Cell Therapy Strategies
Objective: Define polydatin's therapeutic mechanism targeting astrocyte-mediated neuroinflammation in Parkinson's disease (PD) and assess combinatorial efficacy with dopamine progenitor transplantation. Background: PD progression involves substantia…Neural Correlates of Rhythmic Auditory Stimulation Responsiveness in Parkinson’s Disease: A Pilot Gait and fMRI Study
Objective: To compare neural activity differences between Parkinson's disease patients responsive to rhythmic auditory stimulation (RAS-r) and those not responsive (RAS-n) using functional MRI (fMRI).…
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