Evaluating the Efficacy of Home-Based Exercise Interventions for Individuals with Mild to Moderate Parkinson’s Disease: A Systematic Review
Objective: To systematically evaluate the effectiveness of HBEI on motor symptoms, balance, and overall well-being in individuals with mild to moderate PD, providing insights into…Alpha-Synuclein Accumulation-Attenuating Effect of Brain-Derived Neurotrophic Factor in Primary Cell Culture Model of Parkinson’s Disease
Objective: To explore the role of neurotrophic signaling pathways in modulating the effect of brain-derived neurotrophic factor (BDNF) on pre-formed fibrils (PFFs)- induced alpha-synuclein (aSyn)…Glial interaction with Parkinsonian disorders biomarkers: alpha-synuclein, dopaminergic dysfunction and clinical stages
Objective: We aim to investigated the relationship between glial markers and Parkinson's disease. Background: Neuronal α-Synuclein Disease (NSD) has recently been proposed as a framework for…Improving Motor and Non-motor Symptoms in Parkinson’s Disease: A combined Pharmaceutical and Digital Approach Targeting Parallel Neural Circuits
Objective: We aimed to demonstrate the parallel neural mechanisms underlying the effects of combining standard levodopa treatment with the DopApp digital intervention on motor and…GBA1 deficiency promotes the spread of Lewy pathology
Objective: To elucidate how GBA1 deficiency promotes the spread of Lewy pathology from cell to cell. Background: Mutations in the gene glucosidase, beta acid 1 (GBA1) not…Longitudinal Effects of Initial Deep Brain Stimulation Settings on Force-Tracking Brain Activation and Motor Performance in Parkinson’s Disease
Objective: To evaluate changes in force-tracking (FT) fMRI activation patterns and motor performance over time using initial deep brain stimulation (DBS) settings optimized after three…A novel potential imaging biomarker for Parkinson’s disease: Optical Coherence Tomography.
Objective: This observational cross-sectional study aims to explore the thickness of retinal layers in patients within the PD continuum, patients with isolated REM Sleep Behavior…Assessing Genome-wide Genetic Risk for Parkinson’s Disease Age at Onset in European Sub-Populations: from the Global Parkinson’s Genetics Program
Objective: To identify the genetic determinants of Parkinson’s disease (PD) age at onset (AAO) within and across genetically determined European ancestries (European, Ashkenazi Jewish, Finnish,…Distribution of Genomic Ancestries and Genetic Variation Among Individuals Enrolled in the PD GENEration Study
Objective: To assess the distribution of genomic ancestries and rates of positive genetic findings in individuals enrolled in a large-scale return of results study for…Smoking and Genetic Interactions in Parkinson’s Disease
Objective: To investigate the interaction between smoking and Asian-specific LRRK2 variants (G2385R and R1628P) in Parkinson’s disease (PD) risk, examining whether smoking modifies the genetic…
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