Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease
Objective: To integrate mechanistic evidence delineating irisin mediated molecular pathways relevant to Parkinson’s disease (PD) pathogenesis and neuroprotection, focusing on α-syn clearance, autophagy–lysosomal function, mitochondrial…Effectiveness of Acupuncture for Parkinson’s Disease with Mild Cognitive Impairment A Randomized Clinical Trial
Objective: To evaluate the efficacy and safety of acupuncture for PD-MCI, and improve the credibility of acupuncture research evidence through employing a sham acupuncture device…Predicting Parkinson’s: Navigating Risk, Rights, and Regulation
Objective: This study explores the legal and ethical challenges surrounding predictive testing for Parkinson’s disease (PD), with a particular focus on its impact in employment,…Clinical Impact of Nicotine in Parkinson’s Disease: Evidence from Randomized Controlled Studies
Objective: To evaluate the effects of nicotine versus placebo in Parkinson’s disease (PD). Background: Nicotine may influence dopaminergic and non‑dopaminergic pathways relevant to PD. While…Association of Quality of Life with Risk Markers and Prodromal Signs of Parkinson’s Disease in the Population-Based Healthy Brain Ageing Study
Objective: To understand which factors associated with the risk of developing Parkinson's disease (PD) influence quality of life (QoL) in a cohort from the European…Posterior tibial nerve Stimulation in the management of Urinary Disorders in Parkinson’s Disease Experience of the National Hospital Center of Pikine
Objective: Evaluate the efficacy of posterior tibial nerve stimulation in the management of LUTS in patients with PDCompare posterior tibial nerve stimulation to medication Background:…Enteric Alpha-Synuclein Pathology in Early-Onset Parkinson’s Disease and an Incidental Case in Spinocerebellar Ataxia Type 6
Objective: This study aimed to investigate Alpha-synuclein (AS) accumulation in the gastrointestinal (GI) tract of patients with early-onset PD (EOPD). Background: AS accumulation is found…Gut Barrier Failure In Parkinson Disease: Reduced Colonic Resilience In Moderate Disease And Spontaneous Pan-Intestinal Leak In Severe Disease
Objective: To determine whether intestinal barrier dysfunction in Parkinson disease (PD) is stage-specific by assessing baseline epithelial permeability and resilience to inflammatory and microbial stressors.…Evaluating YouTube as a source of health information on Parkinson’s disease
Objective: This study aimed to evaluate the quality, reliability, and engagement characteristics of YouTube videos on Parkinson's disease using standardized assessment tools. Background: Parkinson’s disease…Baseline assessment of nigrostriatal integrity via VMAT2 PET in participants with Parkinson’s disease from the BIIB122/DNL151 LUMA Phase 2b study
Objective: Evaluate nigrostriatal integrity using vesicular monoamine transporter 2 (VMAT2) PET in participants with early-stage PD enrolled in the LUMA study. Background: LUMA is a…
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