Genetic variants detection and prevalence in Hawaii’s diverse PD population
Objective: To overcome access barriers to genetic testing and address the paucity of knowledge regarding genetic causes of PD among Hawaii’s racial and ethnic groups.…Unveiling Parkinson’s Disease Variants in the Chinese Population: The CPD10KGP Study
Objective: In response to these limitations, we are proposing the China Parkinson’s Disease 10,000 Genomes Project (CPD10KGP), which aims to delineate the genetic architecture of…The role of imaging in deep brain stimulation programming: a preliminary comparative study of image-guided vs. neuroimaging-guided automated approaches in Parkinson’s disease
Objective: To evaluate the imaging correlation between image-guided and neuroimaging-guided automated of bilateral STN stimulation in patients with PD. Background: Subthalamic deep brain stimulation (STN-DBS)…Levodopa and DBS Produce Discordant Effects on Parkinsonian Features
Objective: To compare the effect of levodopa vs deep brain stimulation on specific motor features of advanced Parkinson disease. Background: Levodopa (LD) is the gold…Value of local field potential-based deep brain stimulation programming in Parkinson’s disease
Objective: To report preliminary data on the utility of local field potential(LFP)-based programming in bilateral subthalamic nucleus(STN) deep brain stimulation(DBS) for Parkinson’s disease(PD). Background: Current…The Impact of Bilateral GPi Deep Brain Stimulation on Non-Motor Symptoms in Parkinson’s Disease
Objective: This study aimed to evaluate how bilateral Globus Pallidus internus (GPi) Deep Brain Stimulation (DBS) affects non-motor symptoms in individuals diagnosed with Parkinson’s disease…Impact of IPX203 (ER CD-LD) on nighttime sleep in patients with Parkinson’s disease experiencing motor fluctuations: A post hoc analysis of the RISE-PD trial
Objective: To explore the effects of IPX203 on nighttime sleep and motor states in patients with Parkinson’s disease (PD) experiencing motor fluctuations. Background: Sleep disturbances…Risk Factors and Outcome of Dopamine Dysregulation Syndrome in a large Chinese Parkinson’s Disease Cohort
Objective: We conducted a large-sample study to investigate the clinical characteristics and related risk factors of DDS in China. In addition, we further followed up…The role of serotonergic mechanisms in the formation of levodopa-induced drug-induced dyskinesias in Parkinson’s disease
Objective: To study the quantitative content of serotonin and dopamine in the blood plasma of patients with Parkinson's disease and to conduct a clinical and…Alterations in gut microbiota composition in VPS35 associated PARK17 mouse model
Objective: This study explores whether host genetics such as specific VPS35 genetic variations linked to PD can shape the gut microbiome. Background: Heterozygous (D620N) mutation…
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