Latent Clinical States and Longitudinal Transitions in Prodromal Lewy Body Disease: A Data-Driven Analysis from the NaT-PROBE Study
Objective: To elucidate the structure of clinical heterogeneity and longitudinal transition patterns in a prodromal Lewy body disease (LBD) screening cohort using a data-driven approach.…Wearable-Derived Cardiac Features and Cardiac–Motor Interconnection Across Parkinson’s Disease Severities
Objective: To examine how wearable-derived cardiac performance and cardiac–motor interconnection (CCM) vary across Parkinson’s disease (PD) severities, stratified by the Parkinson’s disease–cognitive rating scale (PD-CRS)…Icariin, a Flavonoid from Epimedium, Confers Dopaminergic Neuroprotection and Neuromodulation in MPTP-Induced Parkinsonian Rats
Objective: The present study aims to evaluate the neuroprotective and neuromodulatory properties of icariin in an MPTP-induced Parkinsonian rat model. Background: Parkinson Disease (PD) is…Strengthening Global Parkinson’s Disease Research Capacity through the GP2 ‘Train the Trainer’ Framework
Objective: To implement a sustainable ‘Train the Trainer’ model to strengthen research capacity in Parkinson’s disease (PD) genetics across underrepresented regions (URPs). This initiative promotes…Proximity Ligation Assay Reveals Early Tractopathy in Parkinson’s Disease
Objective: To determine how α-synuclein (αSyn) pathology extends beyond the neuronal soma in the anterior cingulate cortex (ACC) by mapping early pathological changes within adjacent…Analysis of Genetic Variants Associated with Parkinson’s Disease and Depression
Objective: The objective of this study was to evaluate the effect of SNPs in BDNF on depressive symptomatology in a sample of individuals with PD.…The Care Assessment Need Score Underestimates 90-Day Mortality in Veterans with Parkinson’s Disease
Objective: To evaluate the Care Assessment Need (CAN) score as an accurate mortality prediction tool in Parkinson's Disease (PD) to facilitate timely end-of-life care needs…Wearable-Derived Gait Biomarkers Predict Disease Severity and Quality of Life in Parkinson’s Disease: A Machine Learning and Mediation Analysis
Objective: To investigate whether wearable-derived gait biomarkers predict disease severity and health-related quality of life in Parkinson’s disease (PD) and to examine the mediating role…Unravelling the neural correlates of visual cueing in Parkinson’s disease
Objective: Visual cueing can compensate for impaired automatic gait control in Parkinson's disease (PD) patients experiencing Freezing of Gait (FOG) by engaging goal-directed motor behaviour1.…Clinical Approach to Impulse Control–Related Behavioural Disorders in Parkinson’s Disease: A Scoping Review
Objective: We aimed to summarize the definitions, underlying neurobiological mechanisms, validated assessment tools (for both screening and rating), management strategies, and future directions for each…
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