Lived Experience of Parkinson’s Disease in Six African Countries: A Qualitative, Multi-site Transforming Parkinson’s Care in Africa (TraPCAf) Study
Objective: To gain a holistic understanding of life with Parkinson’s disease (PD) in six African countries (Egypt, Ethiopia, Ghana, Kenya, Nigeria and Tanzania), through the…Detection of α-synuclein seeds in skin samples from PPMI participants
Objective: To evaluate the presence of α-synuclein seeds (syn-seeds) in skin samples from PPMI participants, including prodromal, early and late Parkinson’s disease (PD) using a…From Down Under to a Global Audience: Engaging 25,000 People Across 160 Countries to Improve Parkinson’s Knowledge and Awareness
Objective: We aimed to develop a freely accessible massive open online course (MOOC) on Parkinson’s disease, including modules addressing symptoms, diagnosis, underlying biology, medical management,…The Lewy Body Dementia Domain Rating Scale (LBD-DRS): Patient and Care Partner Perspectives
Objective: To develop and validate the Lewy Body Dementia Domain Rating Scale (LBD-DRS), a disease-specific outcome measure designed to comprehensively capture the clinical features and…Agreement Between Patient-Reported Experiences of Daily Living and Clinician-Rated Motor Exam Severity in Parkinson’s Disease
Objective: To assess concordance between patient-reported experiences of daily living and clinician-rated motor exam severity in Parkinson’s disease (PD). Background: Clinicians rate PD motor severity…Expanded Parkinson’s Disease GWAS in African Ancestry Populations Identifies Novel Risk Loci and Precision Medicine Targets
Objective: To conduct the largest genome-wide association study (GWAS) of Parkinson's disease (PD) in African (AFR) and African admixed (AAC) ancestry populations to identify ancestry-specific…Reduced Glucocerebrosidase Activity Is Associated with Cognitive Decline in Severe GBA1-Associated Parkinson’s Disease
Objective: To analyse glucocerebrosidase (GCase1) activity in GBA1-PD patient-derived fibroblasts and blood and to compare it with sporadic PD (sPD) and controls at baseline and…Smartphone-Based Multilingual Application for Remote Screening and Monitoring of Motor Symptoms Associated with Parkinson’s Disease
Objective: This project, funded by the Department of Science and Technology, West Bengal, aims to develop a smartphone-based system for remote screening and monitoring of…Effect of Random Training–Test Splits on Radiomic Classification of Parkinson’s Disease from T1-Weighted MRI in Machine Learning
Objective: Assess the effect of random train–test splits on performance in a small T1-weighted MRI radiomics dataset with machine learning. Background: Radiomic MRI analysis is…Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…
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