Genetic risk modifiers for GBA1 carriers in Parkinson’s disease: from the Global Parkinson’s Genetics Program
Objective: To identify potential genetic risk modifiers for GBA1 variant carriers across genetically determined European ancestries (European, Ashkenazi Jewish, Finnish, and Icelandic) using data from…Digital Health Technology Demonstrates Efficacy of Algorithmic DBS Programming
Objective: To test the feasibility and performance of algorithmic image-guided programming for deep brain stimulation (DBS) using a digital health technology, Quantitative Digitography (QDG), as…Deep Brain Stimulation (DBS) Placement in a Patient with Parkinson’s disease (PD) and Polyostotic Fibrous Dysplasia (PFD)
Objective: To describe a patient who has PD and a history of PFD implanted with DBS. Background: PD is the second most common neurogenerative disorder…Efficacy of Unilateral Focused Ultrasound Subthalamotomy in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate the efficacy of unilateral focused ultrasound subthalamotomy (FUS-STN) in treating patients with Parkinson’s Disease (PD). Background: PD is a neurodegenerative disorder with…Optimizing Electrode Placement in STN-DBS for Parkinson’s Disease: The Added Value of Intraoperative Neurophysiological Monitoring
Objective: This study aims to evaluate the role of intraoperative neurophysiological monitoring, specifically microelectrode recording (MER) and test stimulation, in optimizing electrode placement for deep…Novel Technologies for REM Sleep Behavior Disorder Detection to Identify Prodromal Parkinson’s Disease at Home
Objective: Isolated REM sleep behavior disorder (RBD) is a strong prodromal marker of Parkinson’s disease (PD) and related alpha-synucleinopathies. Early identification is crucial for timely…The discrepancy between self-reported hyposmia and objective assessment by Sniffin’ sticks in high risk of synucleinopathies and healthy controls.
Objective: To study the discrepancy between self-reported hyposmia and the objective assessment of Sniffin’ sticks (identification subset, SS-16) in high risk of synucleinopathy and healthy…A Survey On The Changes Of Non-Motor Symptoms And Quality Of Life In Patients With Parkinson’s Disease After Bilateral Subthalamic Nucleus Deep Brain Stimulation
Objective: This study aims to explore the trajectory of non-motor symptom (NMS) changes in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain…Distribution of Chronotypes in Parkinson’s Disease and its association with Pathological Sleepiness
Objective: To study the distribution of chronotypes in Veterans with Parkinson's disease (PD); and its association with pathological sleepiness. Background: Excessive daytime sleepiness is a…Blood levels of Cathepsin B are linked to a reduced risk of Parkinson’s disease
Objective: To assess the causal impact of plasma Cathepsin B (CTSB) levels on Parkinson’s disease (PD) risk. Background: Cathepsin B is a crucial lysosomal cysteine…
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