The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-onset Parkinson’s Disease
Objective: Survival assessment of PD patients genetically tested at Tel-Aviv Sourasky Medical Center between 2005-2025. We hypothesize that LRRK2-PD would show higher survival rates compared…Interaction Between Physical and Cognitive Function That Determines ADL Improvement in Hospitalized Patients with Parkinson’s Disease: Implications for Individualized Rehabilitation Strategies
Objective: This study aimed to examine factors influencing the degree of improvement in the Barthel Index (BI) among hospitalized patients with PD and to clarify…Effects of Phase-Specific Vibrotactile Cueing on Spatiotemporal Gait Parameters in Parkinson’s Disease
Objective: To evaluate the effects of phase-specific vibrotactile cues applied during swing and stance phases of the gait cycle on spatiotemporal gait parameters in people…The Shape Of Sequence Effect In Parkinson’s Disease
Objective: The aim of this study is to objectively characterize and compare the temporal patterns of finger-tapping amplitude decrement in patients with Parkinson’s disease (PD)…Cross-trait and Multi-polytranscriptomic Score Prediction of Parkinson’s Disease
Objective: To integrate genome-wide association study summary statistics, expression quantitative trait loci (eQTL), individual-level RNA sequencing data and machine-learning approaches to identify molecularly informed cross-trait…A Cerner-based Electronic Prescribing and Medicines Administration (EPMA) Parkinson’s Medicines Care Plan Reduces Time-Critical Medication (TCM) Errors.
Objective: To audit inpatient Parkinson's medication management and implement an EPMA care plan to improve reliability of time-critical prescribing. Background: Parkinson’s UK consistently report that…Association of the GCH1 p.Ser80Asn variant with Parkinson’s disease in East Asian populations
Objective: To investigate the clinical relevance and PD risk associated with the GCH1 p.Ser80Asn variant. Background: Heterozygous variants in GCH1 are the most frequent cause…A Dopamine Clock for Biological Staging of Parkinson’s Disease
Objective: To develop a dopamine transporter (DAT) SPECT imaging staging framework for Parkinson’s disease (PD) using a latent disease-time model that quantifies progression as a…Severity of Psychotic Symptoms Is Independently Associated with Caregiver Burden in Parkinson’s Disease: A Cross-Sectional Analysis
Objective: To evaluate the association between psychotic symptom severity and caregiver burden in patients with PD. Background: Psychotic symptoms are common in Parkinson’s disease (PD)…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…
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