Serum Zinc Reduction During Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in Parkinson’s Disease
Objective: To investigate whether continuous subcutaneous foslevodopa/foscarbidopa infusion reduces serum zinc levels in patients with Parkinson’s disease. Background: Reduced serum zinc levels in Parkinson’s disease…Phase 2 Trial for the Treatment of Early-stage Parkinson’s Disease with TJ0113, a Small Molecule Mitophagy Activator
Objective: To investigate the efficacy and safety of TJ0113 for patients with early-stage Parkinson's disease. Background: Mitochondrial dysfunction, particularly decreased mitophagy, may contribute to the pathogenesis of…Functional Intramuscular Stimulation for Pain in Parkinson’s Disease and Sporadic Amyotrophic Lateral Sclerosis: A Retrospective Case Series
Objective: To describe clinical characteristics and short-term pain outcomes after functional intramuscular stimulation (FIMS) in patients with Parkinson's disease or sporadic amyotrophic lateral sclerosis. Background:…Real-world variability in dosing of continuous subcutaneous foslevodopa/foscarbidopa infusion in advanced Parkinson’s disease: evidence from a single-center cohort
Objective: To evaluate dosing patterns, demographic characteristics, and safety outcomes in patients with advanced Parkinson's Disease (PD) treated with continuous subcutaneous foslevodopa/foscarbidopa infusion in routine…A Genome-Wide Search for Common Variants Modifying Age at Onset in PRKN-Associated Parkinson’s Disease
Objective: The aim of this study was to identify potential genetic modifiers of age at onset in PRKN-associated Parkinson's disease (PD) through a genome-wide association…Predicting Levodopa Responsiveness in Early Parkinson’s Disease Using Neural Perturbation Inference-Based Effective Connectivity
Objective: To investigate the brain network mechanisms underlying individual variability in levodopa responsiveness in Parkinson’s disease (PD) and to evaluate the predictive value of baseline…Age-Modulated Gait Adaptations to Progressive Fatigue in Parkinson’s Disease
Objective: To investigate the effect of progressively increasing perceived fatigue on gait biomechanics in people with Parkinson’s disease (PD), considering the potential moderating role of…Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Gastrointestinal Function in Parkinson’s Disease: A Preliminary Randomized Controlled Trial
Objective: To assess the efficacy and safety of 20/4 Hz transcutaneous auricular vagus nerve stimulation (taVNS) in improving gastrointestinal (GI) function in Parkinson’s disease (PD)…Mutation screening of Miro1 and Miro2 in Parkinson’s disease
Objective: We aimed to systematically evaluate the genetic associations of Miro1 and Miro2 with PD in a large Chinese cohort. Background: Miro1 has been identified to be a novel causative gene…Evaluation of Polygenic Risk Scores Derived from an Updated Cross-European GWAS for Parkinson’s Disease Prediction in European and Ashkenazi Jewish Populations
Objective: To evaluate whether polygenic risk scores (PRS) derived from a recent genome-wide association study (GWAS) improve Parkinson’s disease (PD) prediction compared with PRS derived…
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