Early Indicators of Alpha-synuclein Aggregation: Can Autonomic and Cognitive Markers Predict Prodromal Parkinson’s Disease?
Objective: To develop a model that predicts alpha synuclein (a-syn) status of patients at risk of Parkinson’s disease (PD) using non-motor and cognitive tests that…Safety and tolerability of overnight switching from Eetacapone to Opicapone in fluctuating Parkinson’s disease: An open-label preliminary trial in Koreans
Objective: Objectives: 1. Efficacy - Opicapone 50mg qd. to determine effectiveness of optimal dose for switching. 2. Tolerability and safety - compare symptoms and adverse…A Comparative Analysis of Water-Based versus Land-Based Exercise Interventions for Improving Quality of Life in Parkinson’s Disease: A Systematic Review
Objective: To compare the effectiveness of water-based and land-based exercise interventions in improving quality of life (QoL) and motor function in individuals with Parkinson’s disease…Supporting Movement Disorders Specialists with Digital Tools that Integrate with their Workflows
Objective: Our work investigates how to design digital tools to assist movement disorders specialists in their clinical work. Background: Digital tools are ubiquitous in healthcare;…Frequency of Falls in the Parkinson’s Progression Markers Initiative
Objective: To determine the faller rate across years since diagnosis and neuronal α-synuclein disease integrated staging system (NSD-ISS) stages in the Parkinson's Progression Markers Initiative…Helicobacter Pylori Infection, Peptic Ulcer, Gastritis and Risk of Parkinson´s Disease: a Nationwide Matched Cohort Study
Objective: To examine the potential link between H. pylori infection, gastritis, peptic ulcer and Parkinson’s Disease (PD) risk. Background: Gastrointestinal disorders are frequent among PD…The Impact of Socioeconomic Status on Functionality in people with Parkinson’s Disease
Objective: To investigate the impact of socioeconomic status (SES) on functionality in people with Parkinson's disease (PD) using the World Health Organization Disability Assessment Schedule…Early Impairment in the Immunomodulatory Function of Mesenchymal Stromal Cells Contributes to Heightened Peripheral and Neuroinflammation in Parkinson’s Disease Insights From In Vivo Chronic PD Rat Model and In Vitro PD iPSC Model
Objective: To assess the timeline dependent changes in endogenous Bone-Marrow-Mesenchymal-Stromal-Cells (BMMSC) in in-vivo chronic PD model and validating these cellular modifications in human iPSC derived…The Impact of Microgravity and Herpes Simplex Virus 1 on Parkinson’s Neurodegeneration and HERV Expression
Objective: The present abstract aims to investigate the impact of viral infections and microgravity exposure in the context of Parkinson’s disease (PD). Background: PD is…Decoding Parkinson’s Progression: Longitudinal Volumetric MRI Biomarkers in Prodromal and Clinical Stages
Objective: This study investigates MRI volumetric analysis via VBM as a biomarker for early PD detection, focusing on structural alterations in deep gray matter regions…
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