Baseline assessment of nigrostriatal integrity via VMAT2 PET in participants with Parkinson’s disease from the BIIB122/DNL151 LUMA Phase 2b study
Objective: Evaluate nigrostriatal integrity using vesicular monoamine transporter 2 (VMAT2) PET in participants with early-stage PD enrolled in the LUMA study. Background: LUMA is a…Metabolic-Structural Patterns Across Progressive Supranuclear Palsy Clinical Variants: a Multimodal PET-MRI Study
Objective: To characterize patterns of regional glucose hypometabolism on Fluorodeoxyglucose (FDG)-PET and structural atrophy on MRI across clinical variants of progressive supranuclear palsy (PSP). Background:…Evidence of Systemic and Neuro-Inflammation in Progressive Supranuclear Palsy: Insight from an Imaging-Inflammation Study
Objective: To investigate the role of Th17 pathway in systemic and central inflammation in PSP and to identify signatures of inflammation-induced neurodegeneration in PSP. Background:…Distinct FDG PET Metabolic Signatures and Dopaminergic Loss Across Multiple System Atrophy Subtypes
Objective: To delineate subtype‑specific metabolic networks in Multiple system atrophy (MSA) using FDG‑PET, and to examine how these patterns relate to striatal dopamine transporter (DAT)…Role of florzolotau (18F) positron emission tomography in the diagnosis and clinical management of progressive supranuclear palsy: a real-world study
Objective: This study aimed to evaluate the diagnostic utility of florzolotau (18F) positron emission tomography (PET) and its impact on therapeutic decision-making in patients with…Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Exploratory study of brain 5-HT4 receptor availability in early-stage Parkinson’s disease
Objective: To investigate possible alterations in the 5-HT4 serotonergic receptor in the brain of patients with PD at a relatively early stage, compared with healthy…PET Imaging of Presynaptic Terminals with [18F]SynVesT-1 in Premanifest Huntington’s Disease
Objective: To assess synapse loss in vivo in late premanifest Huntington’s disease (HD) subjects using [18F]SynVesT-1 positron emission tomography (PET). Background: Synaptic damage is believed…Caudate-Predominant Striatal Dopaminergic Deficits in bvFTD with Parkinsonism
Objective: To characterize the dopaminergic lesion pattern in behavioral variant frontotemporal dementia with parkinsonism (bvFTD-P) using dopamine transporter (DAT) positron emission tomography (PET), and to…DTI-ALPS index and its association with dopamine loss, brain metabolism, and motor and cognitive manifestations in Parkinson’s disease
Objective: This study aimed to investigate the clinical relevance of glymphatic dysfunction in Parkinson's disease (PD) by integrating the diffusion tensor imaging (DTI) analysis along…
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