Wide distribution of alpha-synuclein oligomers in Creutzfeldt-Jakob disease detected by a novel proximity ligation assay
Objective: The objective of this work is to assess if oligomeric forms of alpha-synuclein exist in patients with Creutzfeldt-Jakob disease. Background: Prion diseases, the most…Bidirectional gut-to-brain and brain-to-gut propagation of α-synuclein pathology in non-human primates
Objective: The prototypic synucleinopathy Parkinson's disease (PD) is hypothesized to spread out from the enteric nervous system (i.e. the gut) via the vagal nerve up…Presence of Lewy dots in the brain of patients with Creutzfeldt-Jakob disease
Objective: We have investigated whether alpha-synuclein deposits exists in the brain of patients with Creutzfelt-Jakob disease Background: Creutzfeldt-Jakob’s disease (CJD) is a prion neurodegenerative disorder…Variable selection using machine-learning to identify new signatures of patient-derived aggregated α-synuclein-induced neurodegeneration in non-human primates
Objective: Emerging evidence strongly suggests that α-synuclein, a major protein component of LB, may be responsible for the spreading of the pathological process within affected…Creutzfeldt-Jakob Disease with Corticobasal Syndrome-Like Onset: Case report
Objective: We present a 56-year-old man patient who diagnosed CJD with CBS-like onset. Background: Creutzfeldt-Jakob disease (CJD) is an untreatable rare human prion disease characterized…Neurofilament light chain levels in cerebrospinal fluid do not discriminate between patients with prion disease and mimics
Objective: To determine whether levels of neurofilament light chain (NFL) in cerebrospinal fluid (CSF) are useful to discriminate between patients with prion disease (PrD) and…An unusual case of sporadic Creutzfeld Jacob disease presenting as acute neuropathy
Objective: To describe an unusual case of sporadic Creutzfeld Jacob Disease (CJD) that initially presented with ascending tingling of lower extremities. Background: Prion diseases are…99mTc-TRODAT-1 SPECT findings in a patient with sporadic Creutzfeldt-Jakob disease
Objective: To report a case of sporadic CJD presenting insomnia,vertigo, ataxia and parkinsonism as first symptoms and describes the 99mTc-TRODAT-1 SPECT findings. Background: CJD is…Colonic α-synuclein: A potential diagnostic biomarker in Parkinson’s disease
Objective: To validate detection of α-synuclein pathology in the gastrointestinal (GI) tract as a diagnostic marker of Parkinson's disease (PD). Background: α-synuclein (ASN) deposition in…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.