Lighting the Torch: Dating the Most Common Recent Ancestor of the PINK1 p.L347P Variant Linked to Parkinson’s Disease in Pacific Populations
Objective: To determine the generational age of the most recent common ancestor (MRCA) of patients homozygous for PINK1 p.L347P, to 1) Test the hypothesis that…The MJFF PRKN/PINK1 Project
Objective: To i) establish an expert consortium on PRKN/PINK1-linked Parkinson’s disease (PD), ii) improve our understanding of genotype-phenotype relationships and disease mechanisms, and iii) establish…Distinct roles of PARK2, PINK1, and LRRK2 in neuroinflammation: resistance and susceptibility in immune-mediated mouse models
Objective: To investigate the impact of PARK2, PINK1, and LRRK2 deficiency on neuroinflammation in aging, using immune-mediated mouse models. Background: Emerging evidence links mitophagy-related genes, including PARK2 (PARKIN), PINK1, and LRRK2, to immune…PINK1 activation improves outcomes in the UQCRC1 models of Parkinson’s disease
Objective: To investigate the role of chronic oxidative phosphorylation (OXPHOS) stress in mitophagy and the therapeutic potential of PINK1 activation in the UQCRC1 models of…Exploring Neuroprotective Role of Natural Compound by Targeting c-Abl Kinase in Parkinson’s Disease
Objective: To explore c-Abl kinase activation and neuron death pathway in Parkinson’s Disease (PD) mouse model. Assess neuroprotection natural compounds, Rosmarinic acid (RA) with proven…Familial parkinson disease A comparative study between LRRK2 and PINK 1 mutations
Objective: Describe the clinical phenotypes of monogenic forms of PD linked to LRRK2 and PINK1 mutations with a view to a comparative study between the…A novel single-cell reporter identifies regulators of the endogenous PINK1-Parkin mitochondrial quality control pathway
Objective: We aimed to identify genome-wide regulators of the PINK1-Parkin pathway using a novel flow cytometry reporter, endogenously tagged MFN2, as a readout of the…Clinico-genetic profile of five patients with PARK-PINK1: A case series from India
Objective: The aim of our study is to describe the clinical features and genetic profile of patients of PARK-PINK1 and to draw correlation with genetic…Genetic study of early-onset Parkinson’s disease in the Malaysian population
Objective: This study aimed to investigate the genetic architecture of EOPD in a multi-ethnic Malaysian cohort. Background: About 5-10% of Parkinson’s disease (PD) cases are…Genotypic and phenotypic spectrum of PINK-1 associated parkinsonism in 44 mutation carriers from 11 Tunisian families
Objective: To characterize the family history and clinical features of mutations of the PINK-1 gene in a cohort of Tunisian patients with Parkinson disease (P.D)…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.