Delayed Parkinsonism Following Japanese Encephalitis: A Case Report with Dopamine Transporter Imaging and L-dopa/DCI treatment
Objective: To report a case of Japanese encephalitis (JE) presenting with thalamic–midbrain lesions followed by delayed parkinsonism confirmed by dopamine transporter imaging. Background: JE is…The Dual Functional Organization of the Substantia Nigra in Parkinson’s Disease
Objective: We applied connectopic mapping to the internal functional organisation of the substantia nigra (SN) in independent cohorts. Background: The human SN is a central…Association of Neurofilament Light Chain with Substantia Nigra Degeneration in Parkinson’s Disease
Objective: This study aims to investigate the association between serum neurofilament light chain (NfL), microstructural changes in the substantia nigra, and clinical manifestations in Parkinson’s…Modeling Levodopa Resistance in Parkinson’s Disease: A Novel Approach Targeting Locus Coeruleus Degeneration
Objective: To develop a Parkinson’s disease (PD) model replicating levodopa (LD) resistance by incorporating degeneration of both the substantia nigra (SN) and locus coeruleus (LC),…Profiling Neural Protein Dopaminylation in Parkinson’s disease
Objective: The hallmark of Parkinson’s Disease is motor dysfunction from the decline in dopaminergic cells in the substantia nigra (SN), leading to the development of…Transcranial sonography in Parkinson’s disease patients
Objective: To present the usage and results of transcranial sonography (TCS) in Parkinson's disease (PD) patients. Background: (TCS) has emerged as a valuable diagnostic tool…Histopathology of long-term implants of peripheral nerve tissue into the substantia nigra of patients with Parkinson’s disease
Objective: To characterize autologous peripheral nerve tissue (PNT) implants into the substantia nigra of individuals with PD who participated in our previous clinical trials. Background:…Predictors of Clinical Benefit from Adaptive DBS Compared to Conventional DBS in Parkinson’s Disease
Objective: To identify patient characteristics predicting adaptive deep brain stimulation (aDBS) superiority over conventional DBS (cDBS) in Parkinson's disease (PD). Background: Adaptive DBS, modulated in…Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI
Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…TM9SF2 Knockdown Decreases Pathological Alpha-synuclein Aggregation In Vivo
Objective: To determine whether knockdown of transmembrane 9 super family 2 (TM9SF2) decreases the formation of alpha-synuclein inclusions and toxicity to nigral neurons in the…
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