Preliminary Report on Neuromelanin-Sensitive MRI Signal change after Allogeneic Bone marrow-derived Mesenchymal Stem Cells therapy: Phase IIa double-blind, randomized controlled trial
Objective: To select the most effective number of repeat doses of mesenchymal stem cells (MSC) delivered intravenously to slow the progression of Parkinson’s disease (PD).…Are GDNF receptors the gatekeepers of GDNF efficacy during progressive nigrostriatal neuron loss?
Objective: To determine if GDNF receptor expression levels in the striatum or substantia nigra (SN) change in relation to differences in tyrosine hydroxylase (TH) and…MPTP-induced structural reorganization of neurons in mice Basal Ganglia: Verifying the sequelae of differential toxicity
Objective: To evaluate the changes in the neuronal arborization of the medium spiny neurons of striatum & substantia nigra neurons, in response to MPTP in…Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Fibrinogen and CFAH: The two putative markers of Parkinson’s disease with cognitive impairment
Objective: To determine the pathogenic potential of fibrinogen and complement factor H (CFAH) in causing Parkinson’s disease (PD) with cognitive impairment (PDCI)-like symptoms using C57BL/6J…Quantity detection of Substantia nigra hyperechogenicity based on digital image analysis for diagnosing Parkinson’s disease
Objective: We aimed to apply digital analysis to quantify hyperechogenicity of Substantia nigra, and explore its clinical value for the diagnosis of PD. Background: Increased…Multimodal MRI assessment of the substantia nigra in premotor and motor stages of parkinsonism
Objective: To investigate substantia nigra (SN) MRI abnormalities through Neuromelanin (NM) and diffusion MRI (dMRI) with Neurite Orientation Dispersion and Density Index (NODDI) in the…Smoking and Substantia Nigra Neuron Density in the Presence and Absence of Lewy Pathology
Objective: Our objective is to examine the association of mid-life smoking with post mortem substantia nigra (SN) neuron density in the presence and absence of…Neuropathological profile of tauopathy in spinocerebellar ataxia type 8
Objective: The purpose of this study is to examine the distribution of tau pathology in brain regions of patients with spinocerebellar ataxia type 8 (SCA8).…Visual Hallucinations and Parkinson’s Disease Neuropathology among Decedents with and without Parkinson’s Disease or Lewy Body Dementia During Life
Objective: The purpose of this report is to examine the association between visual hallucinations during life and substantia nigra (SN) neuron density and Lewy pathology…
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