Characteristics of tremor caused by non-olivary lesion of the medulla oblongata
Objective: We examined the characteristics of tremor caused by lesions of the medulla oblongata, which do not affect the inferior olive. Background: The medulla oblongata…TETRAS applicability and study design in randomized, placebo controlled clinical trial of Cav3 modulation for essential tremor patients.
Objective: We will study CX-8998, a selective Cav3 antagonist with safety data in 194 patients, in the treatment of ET. Few large controlled ET trials…Ataxic gait in subjects with essential tremor and thalamic neurostimulation is caused by posteromedial current spread in the (sub)thalamic area
Objective: We aimed to disentangle a putative role of bilateral thalamic DBS in developing gait-ataxia in subjects with ET. Background: In ET patients with DBS,…Dopamine transporter, depression and anxiety differences between tremor-predominant and non-tremulous PD are already evident within 2 years of PD diagnosis
Objective: PD patients can be partitioned into two groups, denoted Tremor Dominant (PD-TD) and non-tremor-dominant (PD-NTD) based on their MDS-UPDRS III subscores. Is this distinction…Different patterns of spontaneous brain activity between tremor-dominant and postural instability/gait difficulty subtypes of Parkinson’s disease: A resting-state fMRI study
Objective: This study aimed at investigating the subtype-specific patterns of spontaneous brain activity in PD. Background: Postural instability/gait difficulty (PIGD) and tremor-dominant (TD) subtypes of…Structural and functional signature of primary orthostatic tremor
Objective: (1) We aimed to characterize, in primary orthostatic tremor (OT), the structural and functional defects in the cerebellar motor pathways; (2) We correlated the…Effect of L-DOPA on re-emergent tremor in Parkinson’s disease: A neurophysiological assessment
Objective: To conduct a neurophysiological analysis on the postural re-emergence of tremor in PD patients during an acute L-DOPA challenge test. Background: Some patients with…Resetting tremor by single pulse transcranial magnetic stimulation at the motor cortex and the cerebellum in essential tremor and dystonic tremor
Objective: To explore the role of M1 and CB in the pathophysiology of ET and DT by assessing tremor resetting with motor cortex (M1) and…Involvement of cerebellothalamocortical pathway in essential tremor and dystonic tremor
Objective: To explore the role of CTC in the pathophysiology of ET and DT by assessing cerebellar brain inhibition (CBI). Background: The mechanism of tremor…Substantia nigra α4β2 nicotinic cholinergic receptor expression correlates with tremor in Parkinson’s disease
Objective: To investigate the relationship between tremor and α4β2 nicotinic cholinergic receptor (nAChR) expression in brain regions associated with tremor in Parkinson's disease (PD), including…
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