TETRAS applicability and study design in randomized, placebo controlled clinical trial of Cav3 modulation for essential tremor patients.
Objective: We will study CX-8998, a selective Cav3 antagonist with safety data in 194 patients, in the treatment of ET. Few large controlled ET trials…Comparison of the effect of thalamic DBS/coagulation on tremor and thalamic neuronal activity in spinocerebellar ataxia and essential tremor
Objective: To investigate the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA)…Efficacy and safety of incobotulinumtoxinA (inco/A) for essential tremor using kinematics-guided clinical decision support: A randomized, double-blind, placebo-controlled trial
Objective: To demonstrate improvement of arm tremor severity and hand function with kinematics-guided inco/A therapy Background: Botulinum neurotoxin A (BoNT-A) therapy of debilitating tremor symptoms…Open label study of cannabidiol in Parkinson disease
Objective: To determine if cannabidiol (CBD) is tolerated and effective in Parkinson disease (PD) and the dosage needed for a Phase 2 randomized controlled trial.…The occurrence of dopamine-responsive and dopamine-resistant resting tremor in Parkinson’s disease
Objective: To investigate dopamine-responsiveness of resting tremor in Parkinson’s disease Background: Unlike the core Parkinson motor symptom, bradykinesia, resting tremor has a variable response to…Focusing precision and lesion size in cerebello-thalamo-tractotomy by MR imaging-guided high intensity focused ultrasound (MRgFUS)
Objective: Focusing precision in tcMRgFUS tractotomy depends on the ability of the treatment system to compensate for acoustic field distortions induced by the patient skull.…The impact of STN DBS on kinetic tremor in Parkinson’s disease patients
Objective: The aim of the study is to evaluate the impact of STN DBS on kinetic tremor in PD patients in comparison to pharmacologically treated…Unilateral MR-guided high intensity focused ultrasound ablation of the cerebellothalamic tract in essential tremor
Objective: To report interim results of an ongoing trial of unilateral transcranial MR-guided high intensity focused ultrasound (tcMRgFUS) ablation of the cerebellothalamic tract (CTT) in…Toward clinical use of electrode localizations in deep brain stimulation therapy
Objective: To develop an open source software capable of performing electrode localizations certified for clinical use in deep brain stimulation therapy. Background: Deep brain stimulation…Automated Telehealth Diagnostics for Remote Parkinson Monitoring
Objective: To clinically assess and evaluate the impact of automated telehealth diagnostics on patients with Parkinson's disease (PD). Background: A single evaluation in a clinical…
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