MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Vesicle monamine transporter(VMAT2)"

  • MDS Virtual Congress 2020

    Comparison of Safety and Tolerability of Deutetrabenazine (DTBZ) During Titration and Maintenance in Patients With Tardive Dyskinesia (TD)

    K. Anderson, H. Fernandez, H. Barkay, A. Wilhelm, N. Chaijale, A. Send, J.M Savola, M. Gordon (Washington, DC, USA)

    Objective: To compare safety of DTBZ in titration vs maintenance using data from two 12-wk placebo (PBO)-controlled studies (ARM-TD and AIM-TD) and an open-label extension…
  • MDS Virtual Congress 2020

    Real-World Deutetrabenazine Dosing Patterns in Patients With Huntington’s Disease or Tardive Dyskinesia

    R. Ayyagari, A. Wilhelm, J. Alexander, N. Chaijale, V. Garcia-Horton, F. Devine, B. Carroll (Boston, MA, USA)

    Objective: To evaluate real-world treatment patterns and adherence to deutetrabenazine (DTBZ) in patients with Huntington’s disease (HD) or tardive dyskinesia (TD). Background: DTBZ is a…
  • MDS Virtual Congress 2020

    The Impact of Antipsychotic Dose Reduction Within a Medicare Population

    R. Ayyagari, F. Mu, A. Lax, B. Carroll (Boston, MA, USA)

    Objective: To analyze the burden of antipsychotic (AP) dose reduction in Medicare patients with schizophrenia (SZ). Background: Tardive dyskinesia (TD) develops in patients treated with…
  • MDS Virtual Congress 2020

    Deutetrabenazine Reduces Involuntary Movements in Patients Most Severely Impacted by Tardive Dyskinesia in a 3-year Open-Label Extension Trial

    J. Bona, H. Barkay, A. Wilhelm, N. Chaijale, M. Gordon (Atlanta, GA, USA)

    Objective: To evaluate the efficacy of deutetrabenazine (DTBZ) in reducing TD in the most severely impacted patients using data from an ongoing open-label extension (OLE)…
  • MDS Virtual Congress 2020

    Long-Term Treatment With Deutetrabenazine (DTBZ) Is Associated With Continued Improvement in Tardive Dyskinesia (TD): Results From the Completed, 3-year Open-Label Extension (OLE) Study

    R. Hauser, H. Barkay, H. Fernandez, S. Factor, J. Jimenez-Shahed, N. Gross, L. Marinelli, A. Wilhelm, M. Gordon, J.M Savola, K. Anderson (Tampa, FL, USA)

    Objective: To evaluate long-term efficacy and safety of DTBZ in patients with TD by examining change from baseline in Abnormal Involuntary Movement Scale (AIMS) scores…
  • MDS Virtual Congress 2020

    Long-term Safety and Efficacy of Deutetrabenazine in Younger and Older Patients With Tardive Dyskinesia

    M. Sajatovic, A. Wilhelm, S. Finkbeiner, H. Barkay, N. Chaijale, N. Gross, M. Gordon (Cleveland, OH, USA)

    Objective: To assess the long-term safety and efficacy of deutetrabenazine in younger (<55 years) and older (≥55 years) patients with tardive dyskinesia (TD). Background: TD…
  • MDS Virtual Congress 2020

    Mechanisms of chronic neuroleptic-induced parkinsonism examined with positron emission tomography

    M. Galoppin, P. Berroir, J. Soucy, E. Stip, P. Blanchet (Montreal, QC, Canada)

    Objective: To investigate the cause of chronic neuroleptic drug-induced parkinsonism (NIP) through examination of the profile of striatal monoaminergic nerve terminal density using positron emission…
  • MDS Virtual Congress 2020

    Patient Perspective of Tardive Dyskinesia: Results from a Social Media Listening Study

    L. Lundt, M. Farrar, E. Franey, C. Yonan (San Diego, CA, USA)

    Objective: To use social media listening (SML) to understand the impact of symptoms on patients with assumed/self-reported tardive dyskinesia (TD). Background: TD is a persistent…
  • MDS Virtual Congress 2020

    Real-World Use and Impact of VMAT2 Inhibitors in Patients with Tardive Dyskinesia

    L. Lundt, E. Franey, C. Yonan (San Diego, CA, USA)

    Objective: To describe symptom impact and treatment outcomes in patients prescribed vesicular monoamine 2 (VMAT2) inhibitors for the treatment of tardive dyskinesia (TD). Background: TD,…
  • MDS Virtual Congress 2020

    Evaluation of the Safety of Deutetrabenazine at Higher Doses to Treat Chorea in Huntington’s Disease

    S. Frank, C. Vaughan, D. Stamler, D. Oakes, M. Davis, N. Gross, M. Gordon, J.M Savola, M. Wieman, S. Eberly, E. Kayson, J. Whaley, J. Goldstein, C. Testa (Boston, MA, USA)

    Objective: To evaluate the safety and tolerability of deutetrabenazine >48 mg/d compared to ≤48 mg/d to treat Huntington’s disease (HD)–associated chorea in ARC-HD. Background: In…
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