Inhaled levodopa (LD) as a treatment for Parkinson’s disease (PD) patients in an emergency setting
Objective: To report on use of CVT-301 (inhaled LD) to treat PD patients with complicated OFF period symptoms who present to the emergency department (ED).…Intrinsic brain functional connectivity predicts treatment-related motor complications in drug-naive Parkinson’s disease patients
Objective: Using resting-state functional MRI, we investigated intrinsic brain networks connectivity at baseline in a cohort of drug-naïve Parkinson’s disease (PD) patients which successively developed treatment-related…Psychometric properties of clinical indicators of device-aided therapy eligibility among Parkinson’s disease patients: Real-world data from 6 countries
Objective: Evaluate the performance of clinical indicators for Device-aided Therapy (DAT) eligibility in real-world setting. Background: Timely initiation of appropriate DAT may improve quality of…Non-Motor Fluctuations in Parkinson’s Disease (PD): Development and Validation of the Non-Motor Fluctuation Assessment Instrument (NoMoFA)
Objective: Validate and demonstrate reliability of the NoMoFA. Background: In patients with PD, sleep, mood, cognitive, autonomic and other non-motor symptoms (NMS) may fluctuate (NMF)…Early detection of Parkinson’s disease motor fluctuations with a wearable inertial sensor
Objective: To assess the utility of a wearable inertial sensor for detecting motor complications in Parkinson’s disease (PD) and its usability. Background: Identifying motor complications…Frequency of Wearing-Off Symptoms in Parkinson’s disease Fluctuators: An on/off evaluation
Objective: To determine if the frequency of wearing-off symptoms in Parkinson’s disease (PD) patients who report fluctuations differs from patients without fluctuations. Background: Wearing-off, the…Feasibility of a simplified, symptom-based electronic diary to improve evaluation of motor and non-motor complications in Parkinson’s disease
Objective: To determine the feasibility of the simplified and symptom-based electronic PD diary and compare with the standard paper diary. Background: Motor complications (MC) is…Prevalence, impact, and factors associated with excessive buccal saliva in the COPARK database
Objective: To describe the prevalence of sialorrhea and drooling in Parkinson’s Disease (PD) patients of the COPARK study, to find factors associated to these conditions,…Real-World Evidence for a Smartwatch-based Parkinson’s Motor Assessment App in Patients Undergoing Therapy Changes
Objective: We sought to investigate patient and clinician usability of a smartwatch-based wearable motor assessment system for measuring Parkinson’s disease (PD) motor symptoms in patients undergoing…CVT-301 treatment provides consistent and clinically significant improvements in Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) over 12 weeks
Objective: A post hoc analysis of UPDRS-III sequential changes over the 12-week treatment period of a phase 3 study. Background: CVT-301 is an inhaled levodopa…
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