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Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Wearing-off fluctuations"

  • 2018 International Congress

    The BlueSky Project: monitoring motor and non-motor characteristics of people with Parkinson’s disease in the laboratory, a simulated apartment, and home and community settings

    K. Erb, J. Daneault, S. Amato, P. Bergethon, C. Demanuele, T. Kangarloo, S. Patel, V. Ramos, D. Volfson, P. Wacnik, H. Zhang, D. Karlin, H. Huggins, L. Soll, G. Costante, G. Vergara-Diaz, F. Parisi, J. Banghu, C. Brooks, C. Dethridge, A. Abrami, E. Bilal, V. Caravagio, S. Heisig, R. Norel, E. Pissadaki, J. Rice, B. Ho, K. Thomas, P. Bonato (Cambridge, MA, USA)

    Objective: We present data collected for the BlueSky Project which aims to develop novel assessments of motor and non-motor function using mobile and wearable technology.…
  • 2018 International Congress

    Efficacy of sublingual apomorphine film (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease: Results from the Phase 3 double-blind, placebo-controlled trial

    S. Factor, S. Isaacson, K. Sciarappa, P. Bhargava, G. Vakili, A. Agro, D. Blum, W. Olanow, B. Navia (Atlanta, GA, USA)

    Objective: To evaluate the efficacy of APL-130277 (APL) in a double-blind, placebo-controlled trial. Background: OFF episodes are a common, disabling complication of Parkinson’s disease (PD)…
  • 2018 International Congress

    The Levodopa Response Trial and the Parkinson Disease Digital Biomarker Challenge: Monitoring symptoms of Parkinson’s disease in the lab and home using wearable sensors

    J. Daneault, G. Vergara-Diaz, G. Costante, E. Fabara, G. Ferreira-Carvalho, F. Golabchi, F. Parisi, S. Sapienza, Y. Chae, P. Snyder, P. Aubin, P. Banda, D. Brunner, R. Dorsey, L. Mangravite, W. Marks, E. Neto, U. Rubin, E. Soderberg, D. Daeschler, S. Moore, S. Sieberts, L. Omberg, P. Bonato, The Parkinson's Disease Digital Biomarker DREAM Challenge Consortium (Newark, NJ, USA)

    Objective: To leverage a community of researchers and shared wearable data to develop algorithms to estimate the severity of PD specific symptoms. Background: People with…
  • 2018 International Congress

    The BeyoND study: Design and baseline characteristics of a study evaluating the long-term safety of ND0612 for motor fluctuations in Parkinson’s disease

    W. Poewe, F. Stocchi, A. Espay, T. Rachmilewitz Minei, S. Oren, R. Case, K. Kieburtz, C. Olanow (Innsbruck, Austria)

    Objective: Describe the design and baseline characteristics of a long-term (1 year) study of 2 ND0612 dose regimens, with emphasis on systemic and local safety…
  • 2018 International Congress

    Amantadine extended release (Gocovri) reduces dyskinesia and bradykinesia: Evaluation of clinical response with the wearable PKG (Personal Kinetigraph) watch

    N. Chhabria, S. Isaacson, K. Lyons, R. Pahwa (Boca Raton, FL, USA)

    Objective: To determine the effect of bedtime high-dose amantadine extended release (Gocovri) in 50 consecutive patients experiencing motor fluctuations and dyskinesia. Background: Amantadine extended release…
  • 2018 International Congress

    Safinamide effect in patients with Parkinson’s disease and deep brain stimulation

    F. Mancini, A. Di Fonzo, G. Lazzeri, L. Borellini, V. Silano, M. Lacerenza, C. Comi (Milan, Italy)

    Objective: Aim of this retrospective study is to evaluate safety and efficacy of safinamide in the treatment of motor complications in patients with Parkinson’s Disease…
  • 2018 International Congress

    Evaluating the clinical utility of the Parkinson’s KinetiGraph (PKG™) in the remote management of Parkinson’s disease

    T. Dominey, L. Hutchinson, E. Pearson, F. Murphy, L. Bell, C. Carroll (Plymouth, United Kingdom)

    Objective: To evaluate the clinical utility of the Parkinson’s Kinetigraph (PKG™) in the remote management of Parkinson’s disease (PD) in terms of assistance with therapeutic…
  • 2018 International Congress

    Determinants of absence of dyskinesia in Parkinson’s disease patients with treatment beyond 10 years

    R. Ou, Y. Wu, Q. Wei, X. Yuan, Y. Hou, H. Liu, L. Zhang, Y. Chen, B. Cao, X. Chen, H. Shang (Chengdu, China)

    Objective: This study aims to explore the determinants for absence of dyskinesia in patients with Parkinson’s disease (PD) based on a large cohort of Chinese…
  • 2018 International Congress

    Putaminal dopamine depletion in de novo Parkinson’s disease predicts future development of wearing-off

    S.J. Chung, Y. Lee, J.S. Oh, J.S. Kim, P.H. Lee, Y.H. Sohn (Goyang, Republic of Korea)

    Objective: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson’s disease.…
  • 2017 International Congress

    Motor complications and others of therapy but not non-motor symptoms burden predict short-term mortality in non-demented Parkinson´s disease patients

    D. Santos García, E. Suárez Castro, I. Expósito Ruíz, C. Tuñas Gesto, M. Aneiros Díaz, M. López Fernández, T. de Deus, D. Núñez Arias, J. Ernández (Ferrol, Spain)

    Objective: To identify independent risk factors of mortality in a community-based Parkinson´s disease (PD) cohort during prospective long-term follow-up. Specifically, we analized the effect of…
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