Objective: To validate the utility and efficiency of Brief Smell Identification Test Simplified Chinese Version 2 (B-SIT CV2) in Chinese Parkinson’s disease patients and investigate the familiarity of the odors on questionnaire in Chinese population.

Background: The Brief Smell Identification Test was designed specifically in Chinese population however there were no report for the utility of this olfactory test in the diagnosis of Parkinson’s disease in China.

Methods: PD patients recruited from the Movement Disorder Clinic of the Xuanwu Hospital and healthy controls from the Beijing communities from 2014 to 2015. The Brief Smell Identification Test Simplified Chinese Version 2 was applied for olfactory function test and the familiarity of fifty-nine odors questionnaire was performed for the investigation of familiarity of odors.

Results: One hundred and eighteen subjects were participated in the investigation of application of B-SIT, with 45 healthy controls and 73 PD patients. The sensitivity (69.9%), specificity (86.5%), PPV (89.5%) and NPV (63.9%) could reach in the application of B-SIT to identify PD patient. Three thousands and three hundreds fifty-six subjects were enrolled in the odors familiarity investigation, with 1619 subjects in East China group and 1069 subjects in North China group. A quarter odors in the B-SIT were below the 95% of familiarity in the North China group. The odors of Coffee, Smoke, Chocolate and Apple were poor at differentiation of PD from control. 

Conclusions: Although some of the odors in the B-SIT Simplified Chinese version 2 might not be familiar with Chinese population, this olfactory function test could be used in Chinese Parkinson’s disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/validation-of-the-utility-of-brief-smell-identification-test-simplified-chinese-version-2-in-chinese-parkinsons-disease/