Objective: We aimed to analyze the PD related hormonal factors and VP hormonal endothelial factors.

Background: As we know the Vascular Parkinsonism (VP) and Symptomatic Parkinson’s Disease (PD) is very similar, but both the etiology and pathogenesis of the disease is different. VP and PD had to be separated from each other with different techniques and special diagnostic scales, however, now VP and PD are being diagnosed difficultly.

Methods: We chose the cortisol to study the hormonal mechanisms, and Alpha-fetoprotein concentration to analyze the endothelial factors; we conducted this research from 02.09.2015 till 01.01.2017 in the 1^st Clinic of Tashkent Medical Academy. A total of 87 patients were participated in our investigation, 44 patients of them are suffering from VP, whereas 43 patients are with PD. All patients were tested anamnestic, neurological and neuropsychological examination. We used the MMSE and Khachinskiy scale methods; moreover we studied cortisol levels and the concentration of Alpha-fetoprotein in blood serum in the morning using immunofluorescence methods.

Results: According to the results of the investigation the concentration of cortisol was doubled in 20 patients with VP (45%), 7 patients (15.9%) showed the increase by 1,5 times, and the concentration of cortisol was not changed in 17 patients (38.6%). The patients with PD group, 5 patients (11.6%) showed the increase by 1,5 times in cortisol concentration, the cortisol level doubled in 3 patients (9.3%) and was not changed in 35 patients (79.5%). According to the results of neuropsychological tests and scales the higher levels of cortisol concentration, the higher cognitive impairment was observed in those patients. The Alpha-fetoprotein levels were higher in 23 (52.27%) patients with VP, but in 21 patients (47.72%) it was not determined. Finally, the Alpha-fetoprotein levels were higher in 13 (29.51%) patients with PD.

Conclusions: To sum up the mechanisms of VP and PD are different from each other’s, which seem to be the result of hormonal changes. The higher concentration of cortisol in blood serum, the higher cognitive impairments in patients with VP. Cortisol levels always play an important role in the pathogenesis of Cognitive impairments in patients with VP and PD. The concentration of Alpha-fetoprotein is higher in blood serum in patients with PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/secondary-vascular-parkinsonism-in-uzbekistan-hormonal-pathogenetic-effects-and-vascular-immunological-basics/