Objective: Explore the features of cognitive disorders and neuroimaging features of Parkinson’s disease (PD) and Alzheimer’s disease (AD) in the comparative aspect.

Methods: Study 64 patients with cognitive impairment, including 32 patients with PD (mean age 62,8±9,6 years) and 32 patients with AD (mean age 64,1±8,2 years). Assessment of cognitive function carried out using the MMSE and Frontal Assessment Battery (FAB).Study of the patients also applied neuroimaging (MRI) study.

Results: In 11 patients with PD and in all patients with AD diagnosed dementia. The most prominent cognitive deficits observed in patients with AD – an average score of MMSE 19,8±2,3, according to FAB 13,8±1,6; in the group with PD – an average score of MMSE 25,2±2,6, according to FAB 10,2±1,9. Dementia of PD accompanied by an increase of neural disorders, however, come to the fore violation praxis, gnosis, and worsening dysfunction frontal regions. In the group with AD patients with more severe dementia were significantly more severe violations of praxis and gnosis, and neuropsychological symptoms of dysfunction of the temporal divisions and diffuse cortical lesion. PD noted a positive correlation between the aggravation of cognitive disorders and severity of internal cerebral atrophy, and representation leukoaraiosis on imaging studies. There were no significant differences between patients with relatively mild and more severe dementia in Alzheimer’s disease and neuroimaging parameters.

Conclusions: Changes of the symptoms correlated with cognitive and neuroimaging features in PD and AD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/comparative-analysis-of-clinical-and-neuroimaging-features-of-parkinsonism-and-dementia-of-alzheimers-type/