Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Cognition
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: We aimed to investigate the association between arterial stiffness and cognitive function in patients with Lewy body disorder (LBD), including Parkinson disease (PD) and Dementia with Lewy body (DLB).
Background: The brachial-ankle aortic pulse wave velocity (baPWV) is a marker for arterial stiffness, which is associated with cardiovascular diseases. Arterial stiffness is associated with cognitive function in the elderly and patients with Alzheimer disease (AD). Some reports showed arterial stiffness is related with autonomic dysfunction. We hypothesized that arterial stiffness is associated with cognitive function in LBD, which frequently manifested autonomic dysfunction.
Methods: We consecutively included 123 patients with PD, 10 patients with DLB and 27 AD controls. Patient with PD were divided into normal cognition (PD-NC, n=63), mild cognitive impairment (PD-MCI, n=43) and dementia (PD-D, n=17). Arterial stiffness, measured as brachial-ankle pulse wave velocity (baPWV), was compared between PD-NC, PD-MCI, PD-D, DLB and AD. In LBD, we analyzed association between arterial stiffness and cognitive domain with adjustment for age, education year, hypertension, disease duration and smoking history.
Results: Higher baPWV was significantly associated with cognitive decline in patients with LBD (baPWV in PD-D > PD-MCI > PD-NC; DLB > PD-NC). There was no significant difference of baPWV between PD-D, DLB and AD (PD-D, 2139.8 ± 411.6; DLB, 2115.6 ± 695.3; AD, 2040.7 ± 514.4). In LBD, higher baPWV was associated with lower MMSE score (ß ± SE = -0.003 ± 0.001, p= 0.011) and more severe dementia. Higher baPWV was associated lower performance in attention, language, visuospatial function, memory and executive function in LBD.
Conclusions: In patients with LBD, arterial stiffness was associated with cognitive dysfunction. This can suggest vascular brain injury is associated with cognitive dysfunction in LBD.
To cite this abstract in AMA style:
J.Y. LEE, D.-W. Ryu, J.-S. Kim. Association of arterial stiffness with cognition in patients with Lewy body disorder [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/association-of-arterial-stiffness-with-cognition-in-patients-with-lewy-body-disorder/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-arterial-stiffness-with-cognition-in-patients-with-lewy-body-disorder/