Objective: The aim of present study was to evaluate neuromodulatory propensity of Gingko Biloba in rotenone induced Mice Model of Parkinson Disease in terms of improving behavioural and biochemical aspects.

Background: Gingko Biloba is an ancient Chinese tree which have substantial experimental evidence for its neuroprotective potential and their memory enhancement activity. Various reports on potential of Gingko Biloba apllication in neurological disorder has been evaluated in many in-vitro and in-vivo preclinical studies.

Methods: Animals were exposed to rotenone (1mg/kg) for a duration of three weeks showed remarkable diminished in behavioural paradigm (memory, learning and locomotor activity) oxidative protection (decreased activity of superoxide dismutase , catalase and reduced glutathione level , lipid peroxidation and nitrate estimation) and mitochondrial enzyme activity (complex-II succinate dehydrogenase (SDH), complex-III MTT (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl-H-tetrazolium bromide) as compared to normal control group of mice.

Results: Oral administration of Gingko biloba at three different doses (50,100 and 200 mg/kg p.o.) were able to rescue animals significantly by improving behavior parameters ( P <0.001) oxidative damage (P<0.001) and mitochondrial enzyme complex activities (<0.05, P <0.01, P < 0.001) as compared to rotenone induced group (negative control). It is observed that extract of Gingko Biloba act as a neuromodulator by restoring motor deficits and increased the activities of antioxidant and mitochondrial enzymes activity.

Conclusions: The outcome of present study proves neuroprotective role of Gingko Biloba against rotenone induced Parkinson’s in mice and offers a strong explanation for the therapeutic prospective of Gingko biloba in the management of PD .

References: Patricia R. et al., 2012 Effect of a phytopharmaceutical medicine , Ginko biloba extract 761, in an animal model of Parkinson’s disease: Therapeutic perspectives Nutrition journal 28 1081-1088. Lingling H. et al., 2015 Lithium protects dopaminergic cells from Rotenone toxicity via autophagy enhancement BMS Neuroscience 16:82.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuromodulatory-propensity-of-ginko-biloba-to-offset-rotenone-induced-behaviour-and-biochemical-alteration/