Objective: To compare referral and diagnostic time intervals from index symptom to death in PSP/CBD and age-sex matched PD.

Background: Misdiagnosis and delayed diagnosis are common in PSP and CBD. To inform approaches to reduce diagnostic delay it is essential to systematically evaluate patient pathways to diagnosis.

Methods: Cases with a final diagnosis of PSP, CBD, and age-sex matched PD were identified from the Parkinsonism Incidence in North-East Scotland (PINE) study, an incident community based cohort. Using general practitioner, hospital and research records, referral and diagnostic time intervals from index symptom onset to death were recorded.

Results: The referral and diagnostic time intervals from index symptom to death in 28 PSP/2 CBD cases (77.9 [9.1 years], 50% male) and 30 age-sex matched PD cases (77.6 [8.5 years], 50% male) are shown in Table 1.

Conclusions: While the time interval from symptom onset to death was similar in PSP/CBD and age-sex matched PD, referral and diagnostic time intervals were significantly longer in PSP/CBD over the course of the diagnostic pathway. Identifying factors that both improve the timing and destination of referral decision making, and the accuracy and timeliness of diagnosis is necessary.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/referral-and-diagnostic-time-intervals-from-symptom-onset-to-death-in-progressive-supranuclear-palsy-psp-corticobasal-degeneration-cbd-and-parkinsons-disease-pd/