Session Information
Date: Sunday, October 7, 2018
Session Title: Quality Of Life/Caregiver Burden in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To identify the prevelance of frailty in patients with Idiopathic Parkinson’s disease (PD), to describe the relationship between severity of the disease and frailty, to evaluate if timed up and go (TUG) is an eligible test for determination of frailty in Idiopathic PD patients.
Background: Frailty is commonly seen in patients with PD especially aged over 60.
Methods: We conducted a cross-sectional study included 66 patients aged 60 and over in a tertiary hospital. Frailty was assessed by Fried Frailty Index (FFI). Severity of the Idiopathic PD was detected by Hoehn and Yahr (H&Y) scale. Mobility was measured by TUG test. Demographic characteristics and comprehensive geriatric assessment were evaluated by a structured questionnaire. Descriptive statistics and logistic regression were used in analyses. Receiver operating characteristic (ROC) curves were used to identify the discriminative effect of TUG test on frailty.
Results: The numbers of frail, prefrail and robust were 34 (51. 5%), 24 (36. 4%), and 8 (12. 1%), respectively. Multiple binary logistic regression analysis results yielded being female (Odds ratio (OR):11.77, 95% Confidence interval (CI):1.01-142.91), depression (OR:12.56, 95% CI:1.01-162.83), levodopa doses ≥ 400mg (OR:26.78, 95% CI:1.34-535.45) and dependency in instrumental activities of daily living (IADL) (OR:339.18, 95% CI:9.95-11558.97) were significantly associated with frailty. ROC analysis and youden index predicted a TUG test performance >15.36 seconds was strongly associated with frailty with high sensitivity (80%) and specificity (82%) (AUC:0.831).
Conclusions: Frailty is highly prevalent in Idiopathic PD and is an important contributing factor for disabilities besides specific risk factors of the disease. TUG may be a reliable test for prediction of frailty in patients with Idiopathic PD.
References: 1-Ahmed NN, Sherman SJ, Vanwyck D.Frailty in Parkinson’s disease and its clinical implications.Parkinsonism Relat Disord. 2008;14(4):334-7. 2-Powell C.Frailty and Parkinson’s disease: theories and clinical implications.Parkinsonism Relat Disord. 2008;14(4):271-2.
To cite this abstract in AMA style:
F. Fırat Ozer, S. Akın, M. Gultekin, G. Erturk, A. Ekinci. Frailty in Patients with Parkinson’s Disease: Associations with Disability and Timed Up and Go Test [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/frailty-in-patients-with-parkinsons-disease-associations-with-disability-and-timed-up-and-go-test/. Accessed May 18, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/frailty-in-patients-with-parkinsons-disease-associations-with-disability-and-timed-up-and-go-test/