Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Cognition
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of this study was to examine the relationship of serum BDNF levels with cognitive function.
Background: Brain-derived neurotrophic factor (BDNF) is essential for cognitive function, both of which are diminished in people with Parkinson’s disease (PD). However, little is known about the relationship of BDNF with cognitive function in PD.
Methods: BDNF levels were measured in the serum samples of 29 idiopathic PD subjects and 30 age and gender- matched healthy controls using ELISA technique. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) scale.
Results: Serum BDNF levels and MOCA total score were significantly decreased in PD patients when compared to healthy controls (P<0.001). MOCA total score correlated with serum BDNF (r=0.44; P= 0.012). The regression analysis showed that serum BDNF accounted (P=0.019) for 19% of MOCA total score variance.
Conclusions: The data identifies lowered serum BDNF and cognitive function in PD. Additionally; it suggests that BDNF may play a role in the cognitive deficit of PD. Further studies are required to identify the mechanism(s) responsible for the association of BDNF in cognitive decline with PD.
To cite this abstract in AMA style:
H. Khalil, M.A. Alomari, O.F. Khabour, A. Al-Hieshan, J.A. Bajwa. Circulatory levels of BDNF correlate with cognitive deficits in people with Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/circulatory-levels-of-bdnf-correlate-with-cognitive-deficits-in-people-with-parkinsons-disease/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/circulatory-levels-of-bdnf-correlate-with-cognitive-deficits-in-people-with-parkinsons-disease/